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The BIOCARD Study


Summary

The BIOCARD Study (officially entitled "Biomarkers of Cognitive Decline Among Normal Individuals: the BIOCARD cohort") is supported by a grant jointly funded by the National Institute on Aging (NIA) and the National Institute of Mental Health (NIMH). It is an extension of the Family Study/BIOCARD Study begun at NIMH in 1995.

The overarching goal of the BIOCARD Study is to identify biomarkers associated with progression from normal cognitive status to cognitive impairment or dementia, with a particular focus on Alzheimer's Disease. The domains of information collected as part of the study in the past include: cognitive testing, magnetic resonance imaging (MRI), cerebrospinal fluid (CSF), amyloid imaging (using PET-PiB), and blood specimens.

Investigators at the Johns Hopkins University School of Medicine began evaluating participants in 2009. The subjects are seen annually. At each visit there are assessments of medical and cognitive status, as well as acquisition of MRI, CSF, PET-PiB, and blood.

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