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Janet Holbrook, PhD

Associate Professor

Departmental Affiliation(s):

Epidemiology

Contact Information

911 S. Ann Street
Baltimore , Maryland   21231
US        

443-287-5791
775-269-0836

SciVal Experts Research Profile

Education

PhD , Johns Hopkins University , 1999
MPH , University of California, Berkeley , 1988

Overview

My primary interest is in the design, conduct, and analysis of multicenter clinical trials.  Many of the trials we have completed are comparative effectiveness trials - head to head comparisons of competing treatment with patient-centered outcomes. Most of my experience has been in trials of treatments for eye disease and asthma.     

Epidemiology, clinical trials, surrogate outcomes, prospective observational studies. asthma, uveitis

  • Holbrook JT, Wise RA, Gold BD, Blake K, Brown ED, Castro M, Dozor AJ, Lima JJ, Mastronarde JG, Sockrider MM, Teague WG.  Lansoprazole for children with poorly controlled asthma: a randomized clinical trial.  in Children with Asthma.  JAMA 2012; 307(4): 1-9.

  • Holbrook JT, Kempen JH, Prusakowski NA, Altawel MM, Jabs DA.  Challenges in the design and implementation of The Multicenter Uveitis Steroid Treatment (MUST) Trial – Lessons for Comparative Effectiveness Trials.  Clinical Trials 2011;8(6):736-743.

  • Kempen JH, Altaweel MM, Holbrook JT, Jabs DA, Louis TA, Sugar EA, Thorne JE. Randomized comparison of systemic anti-inflammatory therapy versus flucinolone actinide intraocular implant for intermeadiate, posterior and panuveitis: The Multicenter Uveitis Treatment Trial.  Ophthalmology 2011;118(10):736-743.

  • Holbrook JT, Colvin R, Van Natta ML, Thorne JE, Bardsley M, Jabs DA.  Evaluation of the United States Public Health Service guidelines for discontinuation of anti-CMV therapy after immune recovery in patients with CMV retinitis.  Am J Ophthalmology 2011;142(4):628-637.

  • Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group. The MUST Trial: rational, design and baseline characteristics. 2010;149:550-561.