Ying Zhang, MD
Center & Institute Affiliation(s):
Baltimore , Maryland
MD , Birmingham University , 1991
My primary research interest is mechanisms of drug resistance and persistence in Mycobacterium tuberculosis. Drug-resistant TB (MDR-TB, XDR-TB) is an increasing public health problem and poses a significant threat to the disease control. One third of the world population is latently infected with the tubercle bacillus and HIV infection threatens to allow the latent TB to reactivate and worsen the TB situation. Improved understanding of the persistence of tubercle bacillus and the mechanisms of drug resistance, devising more rapid diagnostic tools, as well as developing drugs and vaccines that are active against drug-resistant and persister bacteria are important for better control of TB. For more details, see http://magazine.jhsph.edu/2007/Spring/features/patient_scientist/
We also have international collaborative projects in China to study (1) how MDR-TB/XDR-TB emerges in the field, including analysis of both host and bacterial factors involved and how a peculiar form of rifampin-dependent/enhanced MDR-TB develops and transmits in patients; (2) rapid molecular diagnostic tests and vaccine development; (3) cancer stem cells from patients
Areas of Interest: 1. Mechanisms of persister drug pyrazinamide (PZA) action and resistance in M. tuberculosis 2. Mechanisms of bacterial persistence and L-forms 3. Mycobacterial pathogenesis 4. Development of novel drugs and vaccines targeting persister bacteria 5. Development of novel diagnostic tools for improved detection of TB and drug-resistant TB 6. Cancer stem cell mechanisms and drugs
Molecular Microbiology and Immunology, tuberculosis, mycobacteria, drug resistance, isoniazid, pyrazinamide, dormancy, persistence, L-form bacteria, drug and vaccine development, cancer stem cells
1. Identified the first molecular mechanism of resistance to TB drug isoniazid (INH)
Zhang, Y., Heym, B., Allen, B., Young, D., and Cole, S. (1992) The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. [Comment] Nature (London) 358: 591-593.
Zhang, Y., Garbe, T., and Young, D. (1993) Transformation with katG restores isoniazid sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations. Mol. Microbiol. 8: 521-524.
Zhang, Y. (2004). Isoniazid, In William N. Rom and Stuart Garay, ed, TUBERCULOSIS – 2nd Ed, Chapter 49, pp739-758, Lippincott Williams & Wilkins, A Wolters Kluwer Company, New York.
2. Identified the molecular mechanisms of resistance and action for the unique persister drug pyrazinamide (PZA):