John Groopman, PhD
Anna M. Baetjer Professor of Environmental Health
Center & Institute Affiliation(s):
615 N. Wolfe Street
Baltimore , Maryland 21205
410 955 0617
PhD , Massachusetts Institute of Technology , 1979
The research in my program involves the development and application of molecular biomarkers of exposure, dose, and effect from environmental carcinogens. The environmental carcinogens studied include agents that are naturally occurring in the diet as well as those produced as a result of cooking practices. A major emphasis of the research has been in the elucidation of the role of aflatoxins, a common contaminate of the food supply, in the induction of liver cancer in high-risk populations living in Asia and Africa. This work has led to the identification of a very strong chemical-viral interaction between aflatoxin and the human hepatitis B virus in the induction of liver cancer. These biomarkers have also been used in many collaborative molecular epidemiology studies of liver cancer risk and recently employed to assess the efficacy of a number of chemopreventive agents in trials in high-risk aflatoxin-hepatitis B virus exposed populations. This research is now being extended to develop genetic biomarkers of p53 mutations and viral alterations in human samples as early detection of disease biomarkers using a novel mass spectroscopy based method for genotyping developed in the laboratory. Thus, the research in our laboratory focuses on the translation of mechanistic research to public health based prevention strategies.
Honors and Awards
2010 AACR-Prevent Cancer Foundation Award for Excellence in Cancer Prevention Research Award
2008 Gerald N. Wogan Lecture, Massachusetts Institute of Technology
National Cancer Institute Research Career Development Award
Delta Omega Honor Society in Public Health, Alpha Chapter
Phi Beta Kappa
Environmental Health Sciences, Chemical carcinogenesis; environmental carcinogenesis; chemoprevention; cancer prevention and control
Kensler, TW, Ng, D, Carmella, SG, Chen, M, Jacobson, LP, Muñoz, A, Egner, PA, Chen, JG, Qian, GS, Chen, TY, Fahey, JW, Talalay, P, Groopman, JD, Yuan, JM and Hecht, SS. Modulation of the metabolism of air-borne pollutants by broccoli sprout beverages: Results of a short term, cross-over clinical trial in Qidong, China Carcinogenesis, 33:101-7, 2012.
Muñoz, A., Chen, JG, Egner, PA, Marshall, ML, Johnson, JL, Schneider, MF, Lu, JH, Zhu, YR, Wang, JB, Chen, TY, Kensler, TW, and Groopman, JD. Predictive Power of Hepatitis B 1762T/1764A Mutations in Plasma for Hepatocellular Carcinoma Risk in Qidong, China. Carcinogenesis, 32: 860-865, 2011.
Iyer, S. and Groopman, J.D. Interaction of Mutant Hepatitis B X Protein With p53 Tumor Suppressor Protein Affects Both Transcription and Cell Survival. Molecular Carcinogenesis, 50:972-80, 2011
Egner, PA, Chen, J-G, Wang, J-B, Wu, Y, Sun, Y., Lu, J-H., Zhu, J., Zhang, Y-H., Chen, Y-S., Friesen, M.D., Jacobson, L., Muñoz, A., Ng, D., Qian, G-S., Zhu, Y-R., Chen, T-Y., Botting, N.P., Zhang, Q-Z., Fahey, J.W., Talalay, P., Groopman, J.D. and Kensler, T.W. Bioavailability of sulforaphane from two broccoli sprout beverages: Results of a short term, cross-over clinical trial in Qidong, China. Cancer Prevention Research, 4:384-395, 2011.
Kensler, T.W., Roebuck, BD, Wogan, GN and Groopman, JD, Aflatoxin: A 50 Year Odyssey of Mechanistic and Translational Toxicology. Toxicological Sciences, 120: S28-S48, 2011.