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Anthony K. L. Leung, PhD

  • Assistant Professor

Departmental Affiliations

Contact Information

615 N. Wolfe Street
Room E8632
Baltimore, Maryland 21205

410-502-8939
+1 (410) 955 2926

http://www.leunglab.org

SciVal Research Profile

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Education

PhD, University of Dundee, 2003
MBioch, University of Oxford, 1999

Overview

Poly(ADP-ribose) Regulation of microRNA activities

My research program focuses on understanding the relationship between microRNAs and stress in cancers, using biochemical, cellular imaging and genomics approaches. Recently, we discovered that microRNA activity is regulated by poly(ADP-ribose), a "druggable" post-translational modification that is essential in multicellular organisms. Dysregulation in synthesis of poly(ADP-ribose) results in human diseases including cancers. My research program is to characterize how this post-translational affects the activities of RNA-mediated gene regulation and to test whether human diseases can be treated by inhibitors against poly(ADP-ribose) metabolism.

Honors and Awards

2015 Johns Hopkins Catalyst Award

2013 Faculty Innovation Award, Johns Hopkins Bloomberg School of Public Heatlh

2013 Finalist, Agilent Early Career Professor

2011-2013 Idea Award, Department of Defense Breast Cancer Research Program

2007-2010 Special Fellowship, The Leukemia & Lymphoma Society

2004-2007 Long-term Fellowship, Human Frontier Science Program

Jul-Aug 2003 Travelling Fellowship, Journal of Cell Science, Company of Biologist Limited

Jun-Jul 2002 European Advanced Light Microscopy Facility Fellowship, EMBL Heidelberg, Germany

1999-2002 Scholarship, Croucher Foundation, Hong Kong

1999-2002 Overseas Research Scheme Award, UK

1995-1999 Waugh Scholarship, University of Oxford, UK

1995-1999 Fitzgerald Prize, University of Oxford, UK

  • Poly(ADP-ribose), microRNAs, Cancers, RNA regulation, RNA granules, stress responses, therapeutic siRNAs, host-pathogen interactions, high-resolution imaging, quantitative proteomics, bioinformatics

Selected publications (5 out of 28); team members are underlined.

  • Daniels CM, Ong SE, Leung AK.  The Promise of Proteomics for the Study of ADP-ribosylation. Molecular Cell 2015 PMID: 26091340

  • Daniels CM, Ong SE, Leung AK. Phosphoproteomic Approach to Characterize Protein Mono- and Poly(ADP-ribosyl)ation Sites from Cells. Journal of Proteome Research 2014 PMID: 24920161

  • Leung AK. Poly(ADP-ribose): An organizer of cellular architecture. Journal of Cell Biology 2014 PMID: 24914234

  • Leung AK, Vyas S, Rood JE, Bhutkar A, Sharp PA, Chang P. Poly(ADP-ribose)
    regulates stress responses and microRNA activity in the cytoplasm. Mol Cell. 2011
      PMID: 21596313

    Leung AK, Vyas S, Rood JE, Bhutkar A, Sharp PA, Chang P. Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Molecular Cell 2011  PMID: 21596313

  • Leung AK, Young AG, Bhutkar A, Zheng GX, Bosson AD, Nielsen CB, Sharp PA.
    Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells 
    with and without mature microRNAs. Nat Struct Mol Biol. 2011  PMID: 21258322

    Leung AK, Young AG, Bhutkar A, Zheng GX, Bosson AD, Nielsen CB, Sharp PA. Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs. Nature Structure and Molecular Biology 2011  PMID: 21258322