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Anthony K. L. Leung, PhD

  • Assistant Professor

Departmental Affiliations

Contact Information

615 N. Wolfe Street
Room E8632
Baltimore, Maryland 21205

410-502-8939
+1 (410) 955 2926

Lab Webpage
http://www.facebook.com/leunglab

SciVal Research Profile

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Education

PhD, University of Dundee, 2003
MBioch, University of Oxford, 1999

Overview

Dr. Anthony Leung – a scientist and an inventor – is an expert in the area of RNA, ADP-ribosylation and proteomics. Dr. Leung completed his four-year Master in Biochemistry degree at the Exeter College, University of Oxford. Funded by the Croucher Scholarship from Hong Kong and Overseas Research Scheme from United Kingdom, Dr. Leung earned his Ph.D. in Biochemistry from the University of Dundee under the guidance of Dr. Angus I. Lamond. Using quantitative proteomes and imaging approaches, Dr. Leung characterized the nucleolar proteome dynamics and discovered a novel nucleolar localization pathway during his Ph.D. In 2004, Dr. Leung was awarded the Human Frontier Science Program Long-term Fellowship and, subsequently in 2007, a Special Fellowship from The Leukemia & Lymphoma Society to perform postdoctoral research on microRNAs under the mentorship of Nobel Laureate Dr. Phillip A. Sharp at MIT. In 2010, Dr. Leung hold a secondary postdoctoral appointment with Dr. Paul Chang at MIT on investigating a therapeutically important protein modification called ADP-ribosylation. Dysregulation of ADP-ribosylation metabolism results in neurodegenerative disorders, virus infection and cancer susceptibility.

In 2011, Dr. Leung started his lab as an Assistant Professor in the Department of Biochemistry and Molecular Biology at Johns Hopkins University. Funded by the Idea Award from the Department of Defense Breast Cancer Research Program, Dr. Leung developed a novel non-biased technique to identify the sites of ADP-ribosylation – a technical breakthrough of the field. He was since then recognized with numerous accolades: Top 5 Agilent Early Career Professor (2013), the Inaugural Johns Hopkins Catalyst Award (2015), Research Scholar Award from the American Cancer Society (2016), and Top 10 Finalist for the American Society of Cell Biology–Gibco Emerging Leader Prize (2016). Dr. Leung has authored over 40 peer-reviewed publications, invited book chapters and review articles. Because of his expertise, Dr. Leung has been frequently invited to review for many scientific journals, serve on editorial boards, chair scientific sessions and speak at international meetings. Dr. Leung is highly collaborative on multidisciplinary projects and grants with experts in virology (Dr. Diane Griffin), oncology (Dr. Ken Pienta, Dr. Marikki Laiho, Dr. Sandra Gabelli and Dr. Sonia Franco), proteomics (Dr. Shao-En Ong and Dr. Akhilesh Pandey) and single molecule diagnostics (Dr. Al Celedon; Scanogen Inc.). In addition, Dr. Leung actively involves in patient education by initiating direct conversations between basic scientists and cancer survivors.

Honors and Awards

2016 Top 10 Finalist, American Society of Cell Biology–Gibco Emerging Leader Prize

2015 Johns Hopkins Catalyst Award

2013 Faculty Innovation Award, Johns Hopkins Bloomberg School of Public Health

2013 Top 5 Finalist, Agilent Early Career Professor

2011-2013 Idea Award, Department of Defense Breast Cancer Research Program

2007-2010 Special Fellowship, The Leukemia & Lymphoma Society

2004-2007 Long-term Fellowship, Human Frontier Science Program

Jul-Aug 2003 Travelling Fellowship, Journal of Cell Science, Company of Biologist Limited

Jun-Jul 2002 European Advanced Light Microscopy Facility Fellowship, EMBL Heidelberg, Germany

1999-2002 Scholarship, Croucher Foundation, Hong Kong

1999-2002 Overseas Research Scheme Award, UK

1995-1999 Waugh Scholarship, University of Oxford, UK

1995-1999 Fitzgerald Prize, University of Oxford, UK

  • Poly(ADP-ribose)
  • microRNAs
  • Cancers
  • RNA regulation
  • RNA granules
  • stress responses
  • therapeutic siRNAs
  • Chikungunya virus
  • virus infection
  • host-pathogen interactions
  • high-resolution imaging
  • quantitative proteomics
  • bioinformatics

Selected publications (5 out of 39)

  • McPherson RL, Abraham R, Sreekumar E, Ong SE, Cheng SJ, Baxter VK, Kistemaker HA, Filippov DV, Griffin DE, Leung AK. ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence. Proceedings of the National Academy of Sciences of the United States of America. 2017 PMID: 28143925
  • Vivelo CA, Wat R, Agrawal C, Tee HY, Leung AK. ADPriboDB: The database of ADP-ribosylated proteins. Nucleic acids research. 2016 PMID: 27507885 http:/ADPriboDB.leunglab.org/
  • Daniels CM, Ong SE, Leung AK.  The Promise of Proteomics for the Study of ADP-ribosylation. Molecular Cell 2015 PMID: 26091340
  • Leung AK. Poly(ADP-ribose): An organizer of cellular architecture. Journal of Cell Biology 2014 PMID: 24914234
  • Leung AK, Vyas S, Rood JE, Bhutkar A, Sharp PA, Chang P. Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Molecular Cell 2011  PMID: 21596313