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Subhra Chakraborty, PhD

  • Assistant Scientist

Departmental Affiliations

Center & Institute Affiliations

Contact Information

615 N. Wolfe Street
Room E5534
Baltimore, Maryland 21205

410-502-2510

View Current Courses

Education

MPH, Johns Hopkins Bloomberg School of Public Health, 2013
PhD, University of Jadavpur, 2004
MSc, University of Burdwan, 1997

Overview

My research is focused on strategies to control diarrhea morbidity and mortality. My research objectives are 1. finding new strategies for improved enteric vaccines and understanding vaccine immunology, 2. delineating the role of the environment in occurrence and transmission of diarrheal pathogens 3. develop new diagnostic tools for resource poor settings to better understand disease epidemiology.

I am involved in evaluation of safety, immunogenicity and efficacy of different candidate enteric vaccines (ACE527 ETEC Vaccine, Fimbrial Tip Adhesin (CfaE) + LTR192G ETEC vaccine, Bioconjugate vaccine against Shigella flexneri 2a, Assessing Rifaximin in preventing campylobacteriosis etc). My objective in these studies is to understand the systemic and mucosal immune responses to different candidate enteric vaccines. The key focus is to find biomarkers for protective immunity using immunoproteome microarray and ELISA, role of memory B cells and T cells. My studies also involves developing and evaluating new assays to better understand the immune responses. We also have developed an experimental challenge model of ETEC in humans. This model facilitates initial evaluation of vaccines thus avoiding the huge expenses and limitations of the efficacy evaluation in the field.We also have (Funding: Gates Foundation, LimmaTech Biologics, Henry M Jackson Foundation)

My other research focus is epidemiology and transmission of enteric pathogens in endemic settings. In Bangladesh, my project is to understand the role of environment in transmission and outbreaks of ETEC. In Peru, we are following a birth cohort to investigate epidemiology, risk factors and protection from ETEC disease. (Funding: NIH R01, Global Health Grant)

My research also involves understanding the role of gut microbiome, transcriptome and other host factors in occurrence and protection from diseases.

Honors and Awards

Women’s Career Development Grant, American Society for Microbiology (ASM), 2008. 

UNESCO-MIRCEN fellowship for the year 2000-2001.

Postdoctoral fellowships, Dept of Infectious disease, School of Medicine, Washington University of St. Louis. 2004-2006

Postdoctoral fellowship, Dept of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University. 2006-2008.

  • Enteric disease
  • Diarrhea
  • Clinical trial
  • Immunology
  • Microbiome
  • Transcriptome
  • Antimicrobial resistance
  • Enterotoxigenic E. coli, Shigella, Cholera, Francisella tularensis
  • Entamoeba histolytica.

Most recent publications

  • Chakraborty S*, Harro C, DeNearing B, Bauers N, Dally L, Flores J, Van de Verg L, Sack DA, Walker R. Evaluation of the Safety, Tolerability and Immunogenicity of an Oral, Inactivated Whole Cell Shigella flexneri 2a Vaccine in Healthy Adult Subjects. Clin Vaccine Immunol. 2016, 23(4):315-25.
  • Pop M, Paulson JN, Chakraborty S (Co first author), Astrovskaya I, Lindsay BR, Li S, Bravo HC, Harro C, Parkhill J, Walker AW, Walker RI, Sack DA, Stine OC. Individual-specific changes in the human gut microbiota after challenge with enterotoxigenic Escherichia coli and subsequent ciprofloxacin treatment. BMC Genomics. 2016, 17(1):440.
  • Chakraborty S*, Harro C, DeNearing B, Ram M, Feller A, Cage A, Bauers N, Bourgeois AL, Walker R, Sack DA. Characterization of Mucosal Immune Responses to Enterotoxigenic Escherichia coli Vaccine Antigens in a Human Challenge Model: Response Profiles after Primary Infection and Homologous Rechallenge with Strain H10407. Clin Vaccine Immunol. 2015 Nov 23(1):55-64.
  • Lindsay BR, Chakraborty S (Co first author), Harro C, Li S, Nataro JP, Sommerfelt H, Sack DA, Colin Stine O. Quantitative PCR and culture evaluation for Enterotoxigenic E. coli (ETEC) associated diarrhea in volunteers. FEMS Microbiol Lett. 2014, 352(1):25-31.
  • Kazi M, Sarkar P, Sheik I, Chakraborty S. Zinc recovers altered intestinial ion-transport and barrier function caused by Shigella infection in T84 cells. FASEB J. 2014, 28(1):902.9