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Josef Coresh, MD

  • Professor

Departmental Affiliations

  • Epidemiology (Primary)
    • Division: Cardiovascular Disease and Clinical Epidemiology
  • Biostatistics (Joint)
  • School of Medicine (Joint)

Center & Institute Affiliations

Contact Information

2024 E. Monument Street, Room 2-635
Suite 2-600
Baltimore, Maryland 21287

410-955-0495
410 955-0476

SciVal Research Profile

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Education

MD, Johns Hopkins School of Medicine, 1992
PhD, Johns Hopkins Bloomberg School of Public Health, 1992
MHS, Johns Hopkins Bloomberg School of Public Health, 1992

Overview

I study risk factors for vascular disease across different organs including the heart, kidney and brain with the goal of improving health and training leaders in research. Much of my work has focused on factors mediating excess risk among patients with various stages of chronic kidney disease (CKD), from pre-clinical to end-stage.  Rigorously defining the burden of CKD in the population is an area I have contributed to since co-chairing the guidelines workgroup which standardized CKD staging (chair, Andrew Levey).  I have enjoyed looking at genetic and biologic risk factors as well as innovative epidemiologic methods and statistical analysis in the conduct of this research. The ultimate objective of my work is to decrease the enormous burden of vascular disease through developing the scientific basis for behavioral and pharmacologic interventions.

Epidemiology and clinical research is most productive when done collaboratively.  I am fortuante to play a leadership role in a number of large collaborations.  Our department, Welch Center and university (Comstock Professorship) produced short videos which partly feature my work and thinking about training future leaders.

Program leadership at Hopkins:

Research projects include leadership roles in:

  •  Atherosclerosis Risk in Communities Study (ARIC) - A prospective study of 15,792 individuals recruited in 1986-1988 and followed for 30+ years for cardiovascular disease and a wide range of other conditions. This NHLBI funded multi-center contract provides the basis for a wide range of ancillary studies which now average over 150 publications annually. A 25-year follow-up examination focused on the vascular basis of cognitive decline and dementia was completed in 2011-2013 on over 6500 individuals (30 and 32 year follow-up visits are being planned).
  • Kidney Disease Collaborative Studies - Co-chairing the National Kidney Foundation guidelines on the definition and classification of kidney disease led to an ongoing line of research.
    • Chronic Kidney Disease Prognosis Consortium (CKD-PC) - Analyzing data from ~60 cohorts across >40 countries including over 5 Million individuals.
    • CKD-EPI Collaboration - The 2009 CKD-EPI Creatinine Equation is replacing the MDRD Study equation as the most widely used equation to estimate GFR globally. Additional studies focus on discovery and validation of novel markers for CKD staging and progression. Recent efforts are focused on novel methods for improved GFR estimation (provisional patent submitted 2014).
    • CKD Biomarkers Consortium - Explores a wide range of markers by multiple groups in a NIDDK U01 grant. Hopkins is now focusing on metabolomics in CKD. 
  • NHANES Kidney Disease Studies - Ongoing efforts to provide the most valid estimates of kidney disease prevalence in the U.S. as well as examine concurrent complications and consequences.  

National committees: My role as vice-chair of the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (KDOQI) workgroup for the Clinical Practice Guideline “Chronic Kidney Disease: Evaluation, Classification and Stratification” has lead to ongoing involvement in the international effort to address the public health burden of chronic kidney disease. This has included contributing to Kidney Disease Improving Global Outcomes(KDIGO) initiative planning controversies meetings in 2004 and 2009 and new guidelines in 2013.

Honors and Awards

2015                  National Kidney Foundation (NKF) David M. Hume Memorial Award - highest honor given to a distinguished scientist-clinician in the field of kidney and urologic diseases

2014-2015        Thomson Reuters Highly Cited Researchers: World’s leading scientific minds top 1% most influential researchers in the world.

2012                  Inaugural George W Comstock Professor – Johns Hopkins University Endowed chair

2012           David M. Levine Excellence in Mentoring Award – Johns Hopkins School of Medicine 

2010           American Heart Association (AHA) Epidemiology and Prevention Mentoring Award

2010                  National Kidney Foundation (NKF) Garabed Eknoyan Award - Making Lives Better for people with kidney disease  

2010                  Co-author on 2009 PNAS paper Cozzarelli Prize for outstanding scientific excellence and originality “Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout” by Owen M. Woodward, Anna Köttgen, Josef Coresh, Eric Boerwinkle, William B. Guggino, and Michael Köttgen

2005                  American Epidemiological Society (AES) membership

1998, 2001,2015 Advising, Mentoring & Teaching Recognition Award, JHSPH

1987                  Medical Scientist Training Program Award, JHU

 

1986                  Princeton University - Phi Beta Kappa, Magna Cum Laude (George B. Wood Legacy Prize - highest academic standing for junior year at Princeton University)

  • Epidemiology - Implement innovative methods to quantify disease burden in the population and its consequences. Cardiovascular Epidemiology - Study the causes and consequences of vascular disease across multiple beds (heart, kidney, brain). Kidney Disease - Develop a strong scientific basis for quantifying the burden, causes, and consequences of kidney disease.  
  • Across the full spectrum of disease, chronic kidney disease (CKD) affects >
  • 10% of US adults (>
  • 20 Million people). Genetic Epidemiology - Quantify the interplay of genes and environment in leading to health and disease. This work is done in collaboration with leading laboratories and specialists.  
  • Collaobrative discoveries include the MYH9/APOL1 susceptiblity locus for kidney disease among African-Americans, and ABCG2 t...

Pubmed has the latest information [>500 entries cited >50,000 times].

  • Frequently cited kidney disease papers:

    Levey AS, Coresh J, Balk E, et al.  National kidney foundation practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Ann Int Med 2003;139:137-147. Times Cited ~ 1829 [summarizes the full guidelines – cited another 4,180 times]

    Coresh J, Selvin E, Stevens LA, et al.  Prevalence of chronic kidney disease in the United States. JAMA 2007; 298: 2038-2047. Times Cited ~ 1,514

    Coresh J, Astor BC, McQuillan G, et al.  Calibration and random variation of the serum creatinine assay as critical elements of using equations to estimate glomerular filtration rate. Am J Kidney Dis 2002; 39: 920-929. Times Cited ~ 472

    Levey AS, Stevens LA, Schmid CH, Yaping (Lucy) Zhang L, Castro A*, MPH2, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J,  CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). Development of a New Equation to Estimate Glomerular Filtration Rate and Comparsion to the Modification of Diet in Renal Disease Study Equation. Ann Int Med. 2009; 604-612. Times Cited ~1559.

    Chronic Kidney Disease Prognosis Consortium, Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J, Gansevoort RT.  Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis.  Lancet. 2010;375:2073-81.  Times Cited ~ 1000 [Coresh J – CKD-PC steering committee chair].

  • Selected recent papers:

    Coresh, J., Turin, T. C., Matsushita, K., Sang, Y., Ballew, S. H., Appel, L. J., Arima, H., Chadban, S. J., Cirillo, M., Djurdjev, O., Green, J. A., Heine, G. H., Inker, L. A., Irie, F., Ishani, A., Ix, J. H., Kovesdy, C. P., Marks, A., Ohkubo, T., Shalev, V., Shankar, A., Wen, C. P., de Jong, P. E., Iseki, K., Stengel, B., Gansevoort, R. T., Levey, A. S., CKD Prognosis Consortium. Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality. JAMA 2014;311:2518-31.PUBMED:24892770 Pubmed Central ID: 4172342

     Koton, S., Schneider, A. L., Rosamond, W. D., Shahar, E., Sang, Y., Gottesman, R. F., Coresh, J. Stroke incidence and mortality trends in US communities, 1987 to 2011. JAMA 2014;312:259-68.PUBMED:25027141

    1.  Coresh, J., Turin, T. C., Matsushita, K., Sang, Y., Ballew, S. H., Appel, L. J., Arima, H., Chadban, S. J., Cirillo, M., Djurdjev, O., Green, J. A., Heine, G. H., Inker, L. A., Irie, F., Ishani, A., Ix, J. H., Kovesdy, C. P., Marks, A., Ohkubo, T., Shalev, V., Shankar, A., Wen, C. P., de Jong, P. E., Iseki, K., Stengel, B., Gansevoort, R. T., Levey, A. S., CKD Prognosis Consortium. Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality. U 2014;311:2518-31.PUBMED:24892770 Pubmed Central ID: 4172342

    2. Koton, S., Schneider, A. L., Rosamond, W. D., Shahar, E., Sang, Y., Gottesman, R. F., Coresh, J. Stroke incidence and mortality trends in US communities, 1987 to 2011. JAMA 2014;312:259-68.PUBMED:25027141

    1. Selected paper on dementia and cognition:

      Alonso A, Mosley T, Gottesman R, Catellier D, Sharrett AR, Coresh J.  Risk of dementia hospitalisation associated with cardiovascular risk factors in midlife and older age: the Atherosclerosis Risk in Communities (ARIC) study.J Neurol Neurosurg Psychiatry. 2009; 80(11):1194-201.

      Schneider AL, Sharrett AR, Patel MD, Alonso A, Coresh J, Mosley T, Selnes O, Selvin E, Gottesman RF. Education and cognitive change over 15 years: the atherosclerosis risk in communities study. J Am Geriatr Soc. 2012; 60(10):1847-53. 

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  • ARIC Cancer
  • Chronic Kidney Disease Prognosis Consortium