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Lawrence J. Appel, MD

  • Professor

Departmental Affiliations

  • School of Medicine (Primary)
  • Epidemiology (Joint)
    • Division: Cardiovascular Disease and Clinical Epidemiology
  • International Health (Joint)
    • Division: Human Nutrition

Center & Institute Affiliations

Contact Information

Welch Center for Prevention
2024 E. Monument Street, Room 2-600
Baltimore, Maryland 21287


SciVal Research Profile

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MPH, Johns Hopkins Bloomberg School of Public Health, 1989
MD, New York University School of Medicine, 1981


I am currently Director of the Welch Center for Prevention, Epidemiology and Clinical Research, a large interdisciplinary research unit that bridges the Schools of Medicine and Public Health at Hopkins.  The mission of the Welch Center is to conduct epidemiologic, clinical and translational research of the highest quality and to train the next generation of interdisciplinary researchers. 

As for my own research, I have conducted clinical research with a particular focus on preventing blood pressure-related cardiovascular and kidney diseases. I have three active lines of research: (1) controlled feeding studies, (2) behavioral intervention trials, that test novel strategies to accomplish lifestyle changes, often related to obesity, and (3) cohort studies and trials related to chronic kidney disease and its consequences. A particularly notable feature of my research is the focus on conditions and diseases that disproportionately afflict minorities and on interventions that have the potential to substantially reduce racial disparities.

Over the course of my carerr, I have mentored numerous students, fellows and faculty (and continue to do so).  This aspect of my career is incredibly enjoyable and rewarding. 

Honors and Awards

2010 Director, Welch Center for Prevention, Epidemiology and Clinical Research

2010 Conner Award Lecturer, American Heart Association 

2008 David M. Levine Excellence in Mentoring Award

2007 Distinguished Lecturer, University of Mississippi School of Medicine

2006 Epidemiologic Inquiry Accolade: Randomized Trial of the Month (OmniHeart) 

2006 Distinguished Researcher, the International Society of Hypertension in Blacks (ISHIB)

2005 Top 4th Percentile in NIH Funding, 1977-2002

  • Cardiovascular disease, kidney disease, hypertension, diet, lifestyle modifications, clincal trials
  • Click Here for Dr. Appel's Full PubMed Listings

  • Appel LJ, Wright JT, Greene T, et al.  Intensive blood-pressure control in hypertensive chronic kidney disease.  N Engl J Med 2010:363(10):918-929.  PMID: 20818902

  • Lloyd-Jones D, Hong Y, Labarthe D, Mozaffarian, D, Appel L, et al.  Defining and Setting National Goals for Cardiovascular Health Promotion and Disease Reduction: The American Heart Association’s Strategic Impact Goal Through 2020 and Beyond. Circulation. 2010;121:586-613. PMID: 20089546           

  • Appel LJ, Anderson CA.  Compelling Evidence for Public Health Action to Reduce Salt Intake,  NEJM 2010; 362:651-2. PMID: 20089959

  • Yeung EH, Appel LJ, Miller ER 3rd, Kao WH. The Effects of Macronutrient Intake on Total and High-molecular Weight Adiponectin: Results From the OMNI-Heart Trial. Obesity (Silver Spring). 2009 Oct 29. [Epub ahead of print] PMID: 19876001