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Valeria
Culotta
,
PhD

Professor

Val Culotta, PhD, examines the role of free radicals and micronutrients in the battle between host and pathogen during fungal infections.

Contact Info

615 N. Wolfe Street, Room W8116
Baltimore
Maryland
21205
US        
410-955-2926

Research Interests

Biochemistry and Molecular Biology; copper; manganese; iron; zinc; antioxidants; ROS; superoxide dismutase; yeast; Candida; infection; pathogens; microbes; metals

Experiences & Accomplishments
Education
PhD
Johns Hopkins University
1987
Overview

Research in the Culotta lab focuses on the role of metal ions and oxygen radicals in biology and disease. Metal ions such as copper, iron and manganese are not only trace nutrients but can be quite toxic. One mechanism of toxicity is through generation of free radicals or so-called reactive oxygen species (ROS) that have been implicated in numerous human disorders from neurodegeneration to cancer and aging to infectious disease. As part of our immune response we attack pathogens through metals and ROS, and successful pathogens have evolved clever ways to thwart these assaults. Using a combination of biochemical, cell biology and molecular genetic approaches we are exploring how microbes and the animals the infect use weapons of metals and ROS at the host-pathogen battleground. Our current emphasis is on the opportunistic fungal pathogen, Candida albicans.

Honors & Awards

MERIT award, National Institutes of Health, General Medicine Sciences.   2005-2015
Elected fellow, AAAS (American Association for Advancement in Science)   1/2011
David Danks Award for Copper homeostasis and its disorders 2014

Select Publications