Josef Coresh, MD
G.W. Comstock Professor
Director, Cardiovascular Epidemiology & Comstock Center
Center & Institute Affiliation(s):
- George W. Comstock Center for Public Health Research and Prevention
- Global Health, Center for
- Welch Center for Prevention, Epidemiology and Clinical Research
2024 E. Monument Street, Room 2-635
Baltimore , Maryland 21287
MD , Johns Hopkins School of Medicine , 1992
PhD , Johns Hopkins Bloomberg School of Public Health , 1992
MHS , Johns Hopkins Bloomberg School of Public Health , 1992
My main research interest is studying risk factors for cardiovascular across different organs including the heart, kidney and brain. I am particularly interested in factors mediating the excess risk of cardiovascular disease among patients with various stages of kidney disease, from pre-clinical to end-stage as well as improving estimates of kidney disease prevalence and consequences. I have enjoyed looking at genetic and biologic risk factors as well as innovative epidemiologic methods and statistical analysis in the conduct of this research. The ultimate objective of this research is to decrease the enormous burden of vascular disease through developing the scientific basis for behavioral and pharmacologic interventions.
Epidemiology and clinical research is most productive when done collaboratively. I am fortuante to play a leadership role in a number of large collaborations.
Program leadership at Hopkins:
- Director, Cardiovascular Epidemiology Training Program (T32HL07024) and area of concentration.
- Director, George W. Comstock Center for Public Health Research and Prevention (GWCC) with over 30 staff members involved in data collection based in Hagerstown, MD.
Research projects include leadership roles in:
- Atherosclerosis Risk in Communities Study (ARIC) - A prospective study of 15,792 individuals recruited in 1986-1988 and followed to 2016 for cardiovascular disease and a wide range of other conditions. The study also includes community surveillance for heart disease incidence trends in four communities. This NHLBI funded multi-center contract provides the basis for a wide range of ancillary studies which results in a total productivity averaging more than 100 publications annually. A 25-year follow-up examination was completed in 2011-2013 on over 6500 individuals.
- Kidney Disease Collaborative Studies - Co-chairing the National Kidney Foundation guidelines on the definition and classification of kidney disease led to an ongoing line of research.
- Chronic Kidney Disease Prognosis Consortium (CKD-PC) - Analyzing data from ~50 cohorts across 40 countries including over 3 Million individuals.
- CKD-EPI Collaboration - The 2009 CKD-EPI Creatinine Equation is replacing the MDRD Study equation as the most widely used equation to estimate GFR. Additional studies focus on discovery and validation of novel markers for CKD staging and progression.
- CKD Biomarkers Consortium
- NHANES Kidney Disease Studies - Ongoing efforts to provide the most valid estimates of kidney disease prevalence in the U.S. as well as examine concurrent complications and consequences.
National committees: My role as vice-chair of the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (KDOQI) workgroup for the Clinical Practice Guideline “Chronic Kidney Disease: Evaluation, Classification and Stratification” has lead to ongoing involvement in the international effort to address the public health burden of chronic kidney disease. This has included contributing to Kidney Disease Improving Global Outcomes(KDIGO) initiative planning controversies meetings in 2004 and 2009 and new guidelines in 2013.
Honors and Awards
2012 David M. Levine Excellence in Mentoring Award
2012 Am. Assoc. for Clinical Chemistry, 2011 Outstanding Speaker Award
2010 American Heart Association’s 2010 Epidemiology and Prevention Mentoring Award
2010 National Kidney Foundation’s Garabed Eknoyan Award for 2010
2010 Co-author on 2009 PNAS paper Cozzarelli Prize for outstanding scientific excellence and originality “Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout” by Owen M. Woodward, Anna Köttgen, Josef Coresh, Eric Boerwinkle, William B. Guggino, and Michael Köttgen
2005 American Epidemiological Society (AES) membership
2003 Inaugural Fellow American Heart Association Council on the Kidney in Cardiovascular Disease
1998,2001 Advising, Mentoring & Teaching Recognition Award, JHU-SHPH
1999 Fellow, American Heart Association Council on Epidemiology and Prevention
Epidemiology, Cardiovascular Epidemiology, Kidney Disease, Genetic Epidemiology, Research Methods, Heart, Kidney
Frequently cited kidney disease papers:
Levey AS, Coresh J, Balk E, et al. National kidney foundation practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Ann Int Med 2003;139:137-147. Times Cited ~ 1829 [summarizes the full guidelines – cited another 4,180 times]
Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA 2007; 298: 2038-2047. Times Cited ~ 1,514
Coresh J, Astor BC, McQuillan G, et al. Calibration and random variation of the serum creatinine assay as critical elements of using equations to estimate glomerular filtration rate. Am J Kidney Dis 2002; 39: 920-929. Times Cited ~ 472
Levey AS, Stevens LA, Schmid CH, Yaping (Lucy) Zhang L, Castro A*, MPH2, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J, CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). Development of a New Equation to Estimate Glomerular Filtration Rate and Comparsion to the Modification of Diet in Renal Disease Study Equation. Ann Int Med. 2009; 604-612. Times Cited ~1559.
Chronic Kidney Disease Prognosis Consortium, Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J, Gansevoort RT. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010;375:2073-81. Times Cited ~ 536 [Coresh J – CKD-PC steering committee chair].
Selected recent papers:
Grams ME, Chow EK, Segev DL, Coresh J. Lifetime Incidence of CKD Stages 3-5 in the United States. Am J Kidney Dis. 2013 Aug;62(2):245-52. doi:10.1053/j.ajkd.2013.03.009. Epub 2013 Apr 6. PMCID: PMC3723711.
Selected paper on dementia and cognition:
Alonso A, Mosley T, Gottesman R, Catellier D, Sharrett AR, Coresh J. Risk of dementia hospitalisation associated with cardiovascular risk factors in midlife and older age: the Atherosclerosis Risk in Communities (ARIC) study.J Neurol Neurosurg Psychiatry. 2009; 80(11):1194-201.
Schneider AL, Sharrett AR, Patel MD, Alonso A, Coresh J, Mosley T, Selnes O, Selvin E, Gottesman RF. Education and cognitive change over 15 years: the atherosclerosis risk in communities study. J Am Geriatr Soc. 2012; 60(10):1847-53.