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Environmental Health and Engineering

Dr. Tang's Recent Publications

  • Tang, W.Y.*, Ho, S.*, Belmonte, J. and Prins, G.S. (2006) Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4, Cancer Research. 2006 June 66(11):5624-5632 * co-first authorship PMID:16740699 (
  • Prins G.S., Tang, W.Y., Belmonte, J. and Ho, S. (2007) Perinatal Exposure to Estradiol and Bisphenol A Alters the Prostate Epigenome and Increases Susceptibility to Carcinogenesis. Basic & Clinical Pharmacology & Toxicology. Feb;102(2):134-8. PMID:18226066. (
  • Ho, S., Tang, W.Y. (2007) Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: an emphasis on fetal-based adult diseases, Reproductive Toxicology.Apr-May;23(3):267-282.PMID:17317097. (
  • Prins G.S., Tang, W.Y., Belmonte, J. and Ho, S. (2008) Developmental exposure to bisphenol A increases prostate cancer susceptibility in adult rats: epigenetic mode of action is implicated. Fertility and Sterility. Feb;89 (2 Suppl):e41. PMID:18308059. (
  • Tang, W.Y, Newbold, R., Mardilovich, K, Jefferson, W, Cheng, R, Medvedovic M., and Ho, S. (2008) Persistent hypomethylation in the promoter of nucleosomal binding protein (Nsbp1) correlates with Nsbp1 overexpression in mouse uteri neonatally exposed to diethylstilbestrol or genistein. Endocrinology July; 149(12):5922-5931. PMID:18669593. (
  • Tsang, T.Y., Tang, W.Y., Tsang, W.P., Co, N.N., Kong, S.K. and Kwok, T.T. (2008) Down regulation of hepatoma-derived growth factor activates the Bad-mediated apoptotic pathway in human cancer cells. Apoptosis. Sep;13 (9):1135-47. PMID: 21336967. (
  • Tang, W.Y.*, Perera, F.*, Herbstman, J.B., Tang, D.T., Levin, L., Miller, R. and Ho, S. (2009) Relation of DNA Methylation of 5'-CpG island of ACSL3 to Transplacental Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Childhood Asthma. PLoS-One. Feb; 4(2).*Co-first authorship. PMID:19221603. (
  • Tsang, T.Y., Tang, W.Y., Tsang, W.P., Co, N.N., Kong, S.K. and Kwok, T.T. (2009) Mechanistic Study on Growth Suppression and Apoptosis Induction by Targeting Hepatoma Derived Growth Factor in Human Hepatocellular Carcinoma HepG2 Cells. Cellular Physiology and Biochemistry. Aug; 24:253-262. PMID:19710540. (
  • Tsang, T.Y., Tang, W.Y., Chan, J.Y., Co, N.N., Au Yeung, C.L., Yau, P.L., Kong, S.K., Fung, K.P., Kwok T.T. (2011). P-glycoprotein enhances radiation-induced apoptotic cell death through the regulation of miR-16 and Bcl-2 expressions in hepatocellular carcinoma cells. Apoptosis. May;16(5):524-35. PMID: 21336967. (
  • Wu T.Y., Giovannucci, E.,Weldge, J., Mallick, P., Lemasters, G., Tang, W.Y. and Ho, S. (2011) Measurement of GST-P1 methylation in body fluids may complement PSA screening for prostate cancer: implication of using plasma and urine samples: a meta-analysis. Br J Cancer. Jun 28;105(1):65-73. PMID: 21654682. (
  • Tang, W.Y., Morey L, Cheung Y.Y., Belmonte, J, Prins, G.S., and Ho, S. (2012) Neonatal exposure to 17β-estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate gland throughout life. Endocrinolgy, Jan 2012;153(1):42-55. PMID:22109888. (
  • Tang, W.Y., Levin, L., Talaska, G., Cheung, Y.Y., Herbstman, J.B., Miller, R., Perera, F., and Ho, S. (2012) Maternal exposure to polycyclic aromatic hydrocarbons is associated with methylation at a 5'-CpG island of interferon-γ in cord white blood cells. Environ Health Perspect. Aug 2012; 120(8): 1195-1200. PMCID: PMC3440069. (
  • Tankersley, C.G., Georgakopoulos, D., Tang, W.Y., and Sborz, N. (2012). Effects of Ozone and Particulate Matter on Cardiac Mechanics: Role of the Atrial Natriuretic Peptide Gene. Toxicol Sci. 2012 Jan;131(1):95-107. PMID: 22977167. (
  • Cheng, R.Y.S. and Tang, W.Y. Environment, Epigenetics and Diseases. (2012). (Book Chapter, "Toxicology and Epigenetics". The John Wiley and Sons Ltd)
  • Shang, Y., Das, S., Xiao, X., Rabold, R., Mitzner, W. and Tang, W.Y. (2013). Investigation of DNA Methylation Changes in House-dust-mite (HDM) Induced Asthma. Am J Respir Cell Mol Biol. 2013 2013 Aug; 49(2):279-87. PMID: 23526225 (
  • Gribble, M., Tang, W.Y., Shang, Y., Pollak, J., Umans, J., Francesconi, K.A., Goessler, W., Silbergeld, E.K, Guallar,E., Cole, S., Fallin, D., and Navas-Acien, A. (2013). Differential methylation of the arsenic (III) methyltransferase promoter according to arsenic exposure. Arch Toxicol. 2013 Oct 24. [Epub ahead of print] PMID: 24154821. (
  • O'Hagan HM, Tang W.Y. Increased understanding of the impact of environmental exposures on the epigenome. Environ Mol Mutagen. 2013 Dec 14. [Epub ahead of print]
  • Cheng, YS., Shan, Y., Limjunyawong, N., Das, S., Hopkins, J., Mitnzer, W and Tang., W.Y. (2014) Epigenomics Approaches in the Investigation of Allergic Airway Hyperresponsiveness. (Environmental and Molecular Mutagenesis, in press)
  • Tellez-Plaza M, Tang, W.Y., Shang, Y., Umans JG., Francesconi, KA., Goessler, W., Pollak, J., Guallar, E., Cole, S., Fallin, D., Navas-Acien, A. (2014) Global DNA Methylation and Global DNA Hydroxymethylation in a Population-based Pilot Sample from the Strong Heart Study. (Environ Health Perspect, in press)(




















































































*Co-authorship; †Corresponding author