Skip Navigation




Courses & Seminars

Events Calendar

Visting Scholars


Funding Opportunities
- Other

Mentoring Program
- For Mentees
- For Mentors

Members Only

Related Links


Roy Ziegelstein, M.D.

Academic Degrees
M.D., Boston University, 1986

Departmental Affiliation
Dept of Medicine – Cardiology

Departmental Address
Department of Medicine A102
4940 Eastern Avenue
Baltimore, MD 21224

Phone: (410)-550-0523, (410)-550-0850
Fax: (410)-550-1094

iplomate in Cardiovascular Disease, The American Board of Internal Medicine
Diplomate in Internal Medicine, The American Board of Internal Medicine
Diplomate, National Board of Medical Examiners

Liberal Arts Alumni Award in Biological Sciences (BU), 1982
Summa cum Laude, Phi Beta Kappa (BU), 1982
Chester S. Keefer Scholarship Award (BU), 1986
University Hospital Student Award (BU), 1986
Alpha Omega Alpha Honor Medical Society (BU), 1986
The Daniel Baker Jr. Memorial Award for Patient Care (JHH), 1989
Certificate of Excellence in Teaching (JHU), 1990
Johns Hopkins University Institutional Research Award, 1992-1993
Johns Hopkins Bayview Medical Center Teaching Award, 1993-1994
Editorial Board, Methods in Cell Science, 1996-
Nominee, JHUSOM/AAMC Humanism in Medicine Award, 2002-2003
Marshall, JHUSOM Graduation Ceremony, 2003

Expertise and Research Interests:

Our laboratory studies calcium signaling in vascular endothelial cells. In particular, we are interested in the role of calcium oscillation frequency in regulating gene expression during inflammation.  We also study basic mechanisms of cardiac valve inflammation in aortic stenosis.


·         Thombs BD, Bernstein DP, Ziegelstein RC, Scher CD, Forde DR, Walker EA, Stein MB. An evaluation of screening questions for childhood abuse in 2 community samples: implications for clinical practice. Arch Intern Med. 2006 Oct 9; 166(18):2020-6.

·         Thombs BD, Grace SL, Ziegelstein RC. Do symptom dimensions of depression following myocardial infarction relate differently to physical health indicators and cardiac prognosis? Am J Psychiatry. 2006 Jul; 163(7):1295-6; author reply 1296.

·         Campbell CY, Record JD, Kolandaivelu A, Ziegelstein RC. Chest pain in a young basketball player. J Gen Intern Med. 2006 Jun; 21(6):C7-10.

·         Ziegelstein RC. What is the answer you got? Am J Med. 2006 Mar; 119(3):288; author reply 289.

·         Ziegelstein RC, Xiong Y, He C, Hu Q. Expression of a functional extracellular calcium-sensing receptor in human aortic endothelial cells. Biochem Biophys Res Commun. 2006 Mar 31; 342(1):153-63. Epub 2006 Feb 3.

·         Thombs BD, Bass EB, Ford DE, Stewart KJ, Tsilidis KK, Patel U, Fauerbach JA,Bush DE, Ziegelstein RC. Prevalence of depression in survivors of acute myocardial infarction. J Gen Intern Med. 2006 Jan; 21(1):30-8. Review.

·         Ziegelstein RC, Thombs BD. The brain and the heart: the twain meet. Eur Heart J. 2005 Dec; 26(24):2607-8. Epub 2005 Oct 14.

·         Hellmann DB, Whiting-O'Keefe Q, Ziegelstein RC, Martin LD, Shapiro E. Revolutionizing the doctor's black bag. A step to revitalizing primary care in medicine. Pharos Alpha Omega Alpha Honor Med Soc. 2005 Summer; 68(3):22-6.

·         Hellmann DB, Whiting-O'Keefe Q, Shapiro EP, Martin LD, Martire C, Ziegelstein RC. The rate at which residents learn to use hand-held echocardiography at the bedside. Am J Med. 2005 Sep; 118(9):1010-8.

·         Nelson RA, Boyd SJ, Ziegelstein RC, Herning R, Cadet JL, Henningfield JE, Schuster CR, Contoreggi C, Gorelick DA. Effect of rate of administration on subjective and physiological effects of intravenous cocaine in humans. Drug Alcohol Depend. 2006 Mar 15; 82(1):19-24. Epub 2005 Sep 6.

·         Zhang S, Wang S, Li Q, Yao S, Zeng B, Ziegelstein RC, Hu Q. Capillary leak syndrome in children with C4A-deficiency undergoing cardiac surgery with cardiopulmonary bypass: a double-blind, randomised controlled study. Lancet. 2005 Aug 13-19; 366(9485):556-62.

·         Fauerbach JA, Bush DE, Thombs BD, McCann UD, Fogel J, Ziegelstein RC. Depression following acute myocardial infarction: a prospective relationship with ongoing health and function. Psychosomatics. 2005 Jul-Aug; 46(4):355-61.

·         Bush DE, Ziegelstein RC, Patel UV, Thombs BD, Ford DE, Fauerbach JA, McCann UD, Stewart KJ, Tsilidis KK, Patel AL, Feuerstein CJ, Bass EB. Post-myocardial infarction depression. Evid Rep Technol Assess (Summ). 2005 May; (123):1-8. Review.

·         Ziegelstein RC, Kim SY, Kao D, Fauerbach JA, Thombs BD, McCann U, Colburn J, Bush DE. Can doctors and nurses recognize depression in patients hospitalized with an acute myocardial infarction in the absence of formal screening? Psychosom Med. 2005 May-Jun: 67(3):393-7.

·         Hooper KM, Boletta A, Germino GG, Hu Q, Ziegelstein RC, Sutters M. Expression of polycystin-1 enhances endoplasmic reticulum calcium uptake and decreases capacitative calcium entry in ATP-stimulated MDCK cells. Am J Physiol Renal Physiol. 2005 Sep; 289(3):F521-30. Epub 2005 May 3.

·         Wright SM, Hellmann DB, Ziegelstein RC. 52 precepts that medical trainees and physicians should consider regularly. Am J Med. 2005 Apr; 118(4):435-8.

·         Ziegelstein RC. Prescribing antitumor necrosis factor drugs to patients with heart failure. Arch Intern Med. 2005 Jan 10; 165(1):118-9.

·         Ziegelstein RC. Wake up and smell the caffeine. Am J Cardiol. 2004 Oct 1; 94(7):981-2.

·         Ziegelstein RC. Near-syncope after exercise. JAMA. 2004 Sep 8; 292(10):1221-6.

·         Ziegelstein RC, He C, Hu Q. Hypoxia/reoxygenation stimulates Ca2+-dependent ICAM-1 mRNA expression in human aortic endothelial cells. Biochem Biophys Res Commun. 2004 Sep 10; 322(1):68-73.

·         Dodd-o JM, Welsh LE, Salazar JD, Walinsky PL, Peck EA, Shake JG, Caparrelli DJ, Ziegelstein RC, Zweier JL, Baumgartner WA, Pearse DB. Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injury. Am J Physiol Heart Circ Physiol. 2004 Aug; 287(2):H927-36.

·         Wright SM, Ziegelstein RC. Writing more informative letters of reference. J Gen Intern Med. 2004 May; 19(5 Pt 2):588-93.

·         Fogel J, Fauerbach JA, Ziegelstein RC, Bush DE. Quality of life in physical health domains predicts adherence among myocardial infarction patients even after adjusting for depressive symptoms. J Psychosom Res. 2004 Jan; 56(1):75-82.

·         Ziegelstein RC, Fiebach NH. "The mirror" and "the village": a new method for teaching practice based learning and improvement and systems-based practice. Acad Med. 2004 Jan; 79(1):83-8.

·         Ziegelstein RC. Low-density lipoprotein cholesterol and post-myocardial infarction depression. Am J Cardiol. 2003 Jun 15; 91(12):1532.

·         Qiu WP, Hu Q, Paolocci N, Ziegelstein RC, Kass DA. Differential effects of pulsatile versus steady flow on coronary endothelial membrane potential. Am J Physiol Heart Circ Physiol. 2003 Jul; 285(1):H341-6.

·         Hu Q, Yu ZX, Ferrans VJ, Takeda K, Irani K, Ziegelstein RC. Critical role of NADPH oxidase-derived reactive oxygen species in generating Ca2+ oscillations in human aortic endothelial cells stimulated by histamine. J Biol Chem. 2002 Sep 6; 277(36):32546-51. Epub 2002 Jul 1.

·         Romanelli J, Fauerbach JA, Bush DE, Ziegelstein RC. The significance of depression in older patients after myocardial infarction. J Am Geriatr Soc. 2002 May; 50(5):817-22.

·         Hu Q, Natarajan V, Ziegelstein RC. Phospholipase D regulates calcium oscillation frequency and nuclear factor-kappaB activity in histamine- stimulated human endothelial cells. Biochem Biophys Res Commun. 2002 Mar 29; 292(2):325-32.


Join the CMBR
Volunteer for a Study
Contact Us
Email this Page  

Subscribe to Newsletter
Locate an Expert

Johns Hopkins MedicineJohns Hopkins Bloomberg School of Public HealthJohns Hopkins University School of Nursing

©, Johns Hopkins University. All rights reserved.
Web policies, 615 N. Wolfe Street, Baltimore, MD 21205