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Gayle Page
Professor & Independence Foundation Chair in Nursing Education

Academic Degrees
DNSc, University of California, Los Angeles, 1992

Departmental Affiliation
School of Nursing – Center for Nursing Research

Departmental Address
525 North Wolfe Street, Room 303
Baltimore, MD 21205

Phone: (410)-955-7484
Fax: (410)-614-1446

My program of research is dedicated to providing evidence that unrelieved pain has significant biologic consequences, and has focused on two areas. In the first area, we have shown that undergoing and recovering from surgery is tumor-promoting, and that providing pain relief significantly ameliorates this consequence. Interventions that have been successful in ameliorating the tumor-enhancing effects of surgery have included systemic morphine (Page et al. 1994; Page et al. 1993; Page et al. 1998), systemic fentanyl and intrathecal bupivacaine (Page et al. 2001), and systemic indomethacin (Page & Ben-Eliyahu, 2002). The second area has focused on the development of NK function in the rat and immune responsiveness to stress in the young animal (Page & Ben-Eliyahu, 1999; Page & Ben-Eliyahu, 2000; Page et al 1995), and most recently the impact of early postnatal pain on responses to both painful and nonpainful stress in the mature animal. Additionally, all of my work has considered the possible sex differences in immunity and responses to stress (Page et al. 2005).

Keywords: pain, immune, endocrine

Honors and Awards:

OSU College of Nursing New Investigator Award, June 1995
Midwest Nursing Research Society Harriet H. Werley New Investigator Award, April 1997
Independence Foundation Endowed Chair, October 1998 – present
Elected Fellow of the American Academy of Nursing, November 1999

Selected Publications

Gill JM, Page GG. Psychiatric and physical health ramifications of traumatic events in women. Issues Ment Health Nurs. 2006 Aug-Sep;27(7):711-34. Review.

Gill JM, Szanton SL, Page GG.  Biological underpinnings of health alterations in women with PTSD: a sex disparity. Biol Res Nurs. 2005 Jul;7(1):44-54. Review. Erratum in: Biol Res Nurs. 2006 Apr;7(4):316.

Woods SJ, Wineman NM, Page GG, Hall RJ, Alexander TS, Campbell JC. Predicting immune status in women from PTSD and childhood and adult violence. ANS Adv Nurs Sci. 2005 Oct-Dec;28(4):306-19.

Woods, A.B., Page GG, O’Campo, P., Pugh, L.C., Ford, D., & Campbell, J.C. (2005). The Mediation Effect of Post-Traumatic Stress Disorder Symptoms on the Relationship of Intimate Partner Violence and IFN-? Levels. American Journal of Community Psychology.

Page GG. Surgery-induced immunosuppression and postoperative pain management. AACN Clin Issues. 2005 Jul-Sep;16(3):302-9; quiz 416-8. Review.

Page GG.  Immunologic effects of opioids in the presence or absence of pain. J Pain Symptom Manage. 2005 May;29(5 Suppl):S25-31. Review.

Page GG, Blakely, W.P., & Kim, M. (2005). The impact of early repeated pain experiences on stress responsiveness and emotionality at maturity in rats. Brain, Behavior, and Immunity, 19, 78-87.

Page GG. The importance of animal research to nursing science. Nurs Outlook. 2004 Mar-Apr;52(2):102-7; discussion 108-10. Review. Page GG, Heitkemper M. Sex: it matters. Biol Res Nurs. 2004 Apr;5(4):241-2.

Yakar, I., Melamed, R., Shakhar, G., Shakhar, K., Rosenne, E., Abudarham, N., Page GG, & Ben-Eliyahu, S. (2003). Prostaglandin E2 suppresses NK activity in vivo and promotes postoperative tumor metastasis in rats. Annals of Surgical Oncology, 10, 469-479.

Page GG. The immune-suppressive effects of pain. Adv Exp Med Biol. 2003;521:117-25. Review.

Page GG, & Ben-Eliyahu, S. (2002). Indomethacin Attenuates the Immunosuppressive and Tumor-Promoting Effects of Surgery. Journal of Pain, 3, 301-308.

Page GG (2002). Analgesia administration attenuates surgery-induced tumor promotion. Regional Anesthesia and Pain Medicine, 27, 197-199.

Lew SR, Page GG, Schuwirth LW, Baron-Maldonado M, Lescop JM, Paget NS, J Southgate L, Wade WB. Procedures for establishing defensible programmes for assessing practice performance. Med Educ. 2002 Oct;36(10):936-41. Schuwirth LW, Southgate L, Page GG, Paget NS, Lescop JM, Lew SR, Wade WB, Baron-Maldonado M. When enough is enough: a conceptual basis for fair and defensible practice performance assessment. Med Educ. 2002 Oct;36(10):925-30.

Rethans JJ, Norcini JJ, Baron-Maldonado M, Blackmore D, Jolly BC, LaDuca T, Lew S, Page GG, Southgate LH. The relationship between competence and performance: implications for assessing practice performance. Med Educ. 2002 Oct;36(10):901-9.


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