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Institute for International Programs

Pathogen-Specific Causes of Diarrhea

Estimation of the Pathogen-Specific Causes of Diarrhea Among Children Under 5 Years of Age and Updated Estimation of the Effectiveness and Herd Effect of the Rotavirus Vaccine (global)

This activity is building off the previous CHERG-led estimates of pathogen specific diarrhea mortality (Lanata et al. Plos One 2013) and estimates by region and by age of diarrhea incidence (Fischer Walker et al. BMC Public Health 2012).  JHU/IIP faculty, in collaboration with faculty at Instituto de Investigacion Nutricional, Peru are estimating the proportion of diarrhea episodes in children under 5 years of age attributable to each of the main diarrhea pathogens.  Those pathogens include; rotavirus, norovirus, adenovirus, astrovirus, EPEC, ETEC, Shigella spp., Campylobacter spp., Cryptosporidium spp., Salmonella spp, Vibrio cholerae O1, and Entamoeba hystolytica.  If sufficient data are found, regional estimates will be made in addition to global estimates.  Through systematic review of the literature, the team is also updated the current estimate of the effectiveness of rotavirus vaccine against rotavirus mortality.