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Institute for International Programs

Simplified Antibiotic Treatment (SAT)

Safety and Efficacy of Simplified Antibiotic Regimens for Outpatient Treatment (SAT) of Suspected Severe Infections in Neonates and Young Infants (Bangladesh)

The Simplified Antibiotic Treatment (a randomized controlled) Trial in Bangladesh provided evidence that simpler antibiotic regimens involving 2 days of injection followed by oral antibiotics for treatment of clinically severe infection in young infants are as efficacious as the standard regimen involving 7 days of injectable antibiotics, thus expanding treatment options for many more infants who live in resource poor settings where hospital care is not accessible.The treatment failure rates (9.8%, 8.3%, and 8.1%), death any time before day 15 follow-up (1.5% to 1.8%), and relapse rates (<2%) similar among all three treatment arms.

Please see the below-listed publications for additional study details.

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