Simplified Antibiotic Treatment (SAT)

Safety and Efficacy of Simplified Antibiotic Regimens for Outpatient Treatment (SAT) of Suspected Severe Infections in Neonates and Young Infants (Bangladesh)

The Simplified Antibiotic Treatment (a randomized controlled) Trial in Bangladesh provided evidence that simpler antibiotic regimens involving 2 days of injection followed by oral antibiotics for treatment of clinically severe infection in young infants are as efficacious as the standard regimen involving 7 days of injectable antibiotics, thus expanding treatment options for many more infants who live in resource poor settings where hospital care is not accessible.The treatment failure rates (9.8%, 8.3%, and 8.1%), death any time before day 15 follow-up (1.5% to 1.8%), and relapse rates (<2%) similar among all three treatment arms.

Please see the below-listed publications for additional study details.

• Zaidi AK, Baqui AH, Qazi SA, Bahl R, Saha S, Ayede AI, Adejuyigbe EA, Engmann C, Esamai F, Tshefu AK, Wammanda RD, Falade AG, Odebiyi A, Gisore P, Longombe AL, Ogala WN, Tikmani SS, Uddin Ahmed AS, Wall S, Brandes N, Roth DE, Darmstadt GL.  Scientific rationale for study design of community-based simplified antibiotic therapy trials in newborns and young infants with clinically diagnosed severe infections or fast breathing in South Asia and sub-Saharan Africa. Pediatr Infect Dis J. 2013 Sep;32 Suppl 1:S7-11. doi: 10.1097/INF.0b013e31829ff5fc.
• Esamai F, Tshefu AK, Ayede AI, Adejuyigbe EA, Wammanda RD, Baqui AH, Zaidi AK, Saha S, Rollins NC, Wall S, Brandes N, Engmann C, Darmstadt G, Qazi SA, Bahl R.  Ongoing trials of simplified antibiotic regimens for the treatment of serious infections in young infants in South Asia and sub-Saharan Africa: implications for policy. Pediatr Infect Dis J. 2013 Sep;32 Suppl 1:S46-9. doi: 10.1097/INF.0b013e31829ff941.
• Wall SN, Mazzeo CI, Adejuyigbe EA, Ayede AI, Bahl R, Baqui AH, Blackwelder WC, Brandes N, Darmstadt GL, Esamai F, Hibberd PL, Jacobs M, Klein JO, Mwinga K, Rollins NC, Saloojee H, Tshefu AK, Wammanda RD, Zaidi AK, Qazi SA.Ensuring quality in AFRINEST and SATT: clinical standardization and monitoring. Pediatr Infect Dis J. 2013 Sep;32 Suppl 1:S39-45. doi: 10.1097/INF.0b013e31829ff801.
• Baqui AH, Saha SK, Ahmed AS, Shahidullah M, Quasem I, Roth DE, Williams EK, Mitra D, Shamsuzzaman AK, Ahmed W, Mullany LC, Cousens S, Wall S, Brandes N, Black RE. Safety and efficacy of simplified antibiotic regimens for outpatient treatment of serious infection in neonates and young infants 0-59 days of age in Bangladesh: design of a randomized controlled trial.Pediatr Infect Dis J. 2013 Sep;32 Suppl 1:S12-8. doi: 10.1097/INF.0b013e31829ff790.

Local Partners

• Child Health Research Foundation
• Hospital for Sick Children
• Shimantik