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Center for Human Nutrition

 

Subhra Chakraborty

Assistant Scientist
Academic Degrees
PhD, MPH, MS
Departmental Affiliation
International Health
Departmental Address
615 N. Wolfe Street, E5534 Baltimore, MD 21205
Research and Professional Experience

My research is focused to reduce mortality and morbidity due to diarrhea in under-served populations. The areas covered are 1) epidemiology and disease burden of enteric infections, 2) vaccine development for enteric diseases.  

Keywords

 Diarrhea, Enteric disease, Clinical trial, Enterotoxigenic E. coli, Cholera, Francisella tularensis, tularemia, Entamoeba histolytica, antimicrobial resistance

Honors and Awards

  1. Women’s Career Development Grant, American Society for Microbiology (ASM), 2008. 
  2. UNESCO-MIRCEN fellowship for the year 2000-2001.
  3. Postdoctoral fellowships, Dept of Infectious disease, School of Medicine, Washington University of St. Louis. 2004-2006
  4. Postdoctoral fellowship, Dept of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University. 2006-2008.

Selected Publications

Michael J. Darsley, Subhra Chakraborty, Barbara DeNearing, David A. Sack , Andrea Feller, Charlotte Buchwaldt, A. Louis Bourgeois, Richard Walker, and Clayton D. Harro. ACE527 Oral, Live Attenuated ETEC Vaccine Reduces the Incidence and Severity of Diarrhea in a Human Challenge Model of Diarrheal Disease. Clin Vaccine Immunol. 2012, Dec;19(12):1921-31.

KM Hoque, Chakraborty, S., Sk, IA., and Owen M. Woodward. New Advances in the Pathophysiology of diarrhea and their impact on therapy. Expert Review of Anti-infective Therapy. 2012, June; 10 (6): 687-699

Clayton Harro, Subhra Chakraborty, Barbara DeNearing, Alicia Marcum, Andrea Feller, Barbora Hnizda, August Bourgeois, Richard Walker, Anna Lundgren, Ann-Mari Svennerholm, and David A. Sack.  Refinement of a human challenge model for evaluation of enterotoxigenic E. coli (ETEC) vaccines. Clin Vaccine Immunol. 2011 Oct;18(10):1719-27.

 Pazhani GP, Chakraborty S, Fujihara K, Yamasaki S, Ghosh A, Nair GB, Ramamurthy T. QRDR mutations, efflux system & antimicrobial resistance genes in entertoxigenic Escherichia coli isolated from an outbreak of diarrhoea in Ahmedabad, India. Indian J Med Res. 2011 Aug;134(2):214-23.

 Harro C, Sack D, Bourgeois AL, Walker R, Denearing B, Feller A, Chakraborty S, Buchwaldt C, Darsley MJ. A Combination Vaccine Consisting of Three Live Attenuated Enterotoxigenic Escherichia coli Strains Expressing a Range of Colonization Factors and Heat-Labile Toxin Subunit B Is Well Tolerated and Immunogenic in a Placebo-Controlled Double-Blind Phase I Trial in Healthy Adults. Clin Vaccine Immunol. 2011 Dec;18(12):2118-27

Subhra Chakraborty, Michael Monfett, Tamara M. Maier, Dara W. Frank, and David G. Thanassi. Type IV pilus biogenesis in Francisella tularensis: pilB and pilT are essential for fiber assembly, adherence and virulenc. Infect Immun. 2008 Jul;76(7):2852-61.

Xhavit Zogaj, Subhra Chakraborty, Jirong Liu, David G. Thanassi, and Karl E. Klose. Characterization of the Francisella tularensis subsp. novicida Type IV Pilus. Microbiology. 2008 Jul;154(Pt 7):2139-50

Paul H. Davis, Zhi Zhang, Minghe Chen, Xiaochun Zhang, Subhra Chakraborty and Samuel L. Stanley Jr. Identification and characterization of a family of Bsp-A like surface proteins of Entamoeba histolytica with novel leucine rich repeats. Molecular and Biochemical Parasitology 2006 Jan;145(1):111-6.

Chakraborty. R., S. Chakraborty, K. Dey, S. Sinha, Mukhopadhyay. AK, Khanam J, T. Ramamurthy, Y. Takeda, S. K. Bhattacharya, and G. Balakrish Nair. Cytotoxic and cell vacuolating activity of Vibrio fluvialis isolated from paediatric patients with diarrhoea. J Med Microbiol. 2005 Aug; 54(Pt 8):707-16.