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Center for Human Nutrition


Lawrence Appel

Academic Degrees
M.D., M.P.H.
Departmental Affiliation
Joint Departmental Affiliations
Epidemiology, International Health
Departmental Address
Welch Center for Prevention, Epidemiology and Clinical Research 2024 E. Monument St., 2-600
Baltimore, MD 21287
Phone: 410-955-4156
Fax: 410-955-0476
Research and Professional Experience

I am currently Director of the Welch Center for Prevention, Epidemiology and Clinical Research, a large interdisciplinary research unit that bridges the Schools of Medicine and Public Health at Hopkins.  The mission of the Welch Center is to conduct epidemiologic, clinical and translational research of the highest quality and to train the next generation of interdisciplinary researchers. 

As for my own research, I have conducted clinical research with a particular focus on preventing blood pressure-related cardiovascular and kidney diseases. I have three active lines of research: (1) controlled feeding studies, (2) behavioral intervention trials, that test novel strategies to accomplish lifestyle changes, often related to obesity, and (3) cohort studies and trials related to chronic kidney disease and its consequences. A particularly notable feature of my research is the focus on conditions and diseases that disproportionately afflict minorities and on interventions that have the potential to substantially reduce racial disparities.

Over the course of my carerr, I have mentored numerous students, fellows and faculty (and continue to do so).  This aspect of my career is incredibly enjoyable and rewarding. 


Cardiovascular disease, kidney disease, hypertension, diet, lifestyle modifications, clincal trials

Honors and Awards

2010 Director, Welch Center for Prevention, Epidemiology and Clinical Research

2010 Conner Award Lecturer, American Heart Association 

2008 David M. Levine Excellence in Mentoring Award

2007 Distinguished Lecturer, University of Mississippi School of Medicine

2006 Epidemiologic Inquiry Accolade: Randomized Trial of the Month (OmniHeart) 

2006 Distinguished Researcher, the International Society of Hypertension in Blacks (ISHIB)

2005 Top 4th Percentile in NIH Funding, 1977-2002

Selected Publications

Click Here for Dr. Appel's Full PubMed Listings

Appel LJ, Wright JT, Greene T, et al.  Intensive blood-pressure control in hypertensive chronic kidney disease.  N Engl J Med 2010:363(10):918-929.  PMID: 20818902

Lloyd-Jones D, Hong Y, Labarthe D, Mozaffarian, D, Appel L, et al.  Defining and Setting National Goals for Cardiovascular Health Promotion and Disease Reduction: The American Heart Association’s Strategic Impact Goal Through 2020 and Beyond. Circulation. 2010;121:586-613. PMID: 20089546           

Appel LJ, Anderson CA.  Compelling Evidence for Public Health Action to Reduce Salt Intake,  NEJM 2010; 362:651...

Lawrence Appel
Research Projects