Tuberculosis (TB) accounts for approximately two million deaths worldwide each year and is the second greatest contributor among infectious diseases to adult mortality. The World Health Organization estimates that more than one-third of the world’s population is infected with Myobacterium tuberculosis (MTB) and more than eight million people with TB infection develop active TB disease each year. If left undiagnosed or untreated, an individual with TB disease may infect between 10 and 15 people each year. TB affects the most productive and economically active segment of the population: morbidity can result in 3-4 months of lost work time and a loss of 20% of annual household income. The GRA Partnership workplan reflects existing and proposed studies to address issues such as multi-drug resistant TB (MDR-TB), co-infection of TB and HIV, and other key areas of research for improving global TB control by promoting strategic research, scientific and programmatic innovation, leadership, and training in high-burden countries. Impact of the "Opt-out" vs. "Opt-in" Strategy on the Uptake of HIV Counseling and Testing of TB Patients, Province of the Eastern Cape, South Africa A Randomized Trial of Novel TB Preventive Regimens for HIV-Infected Adults, Soweto, South Africa TB Prevalence Survey and Evaluation of Access to TB Care in HIV Infected and Uninfected TB Patients, Kenya Multicenter Study of TK Medium for Rapid Detection of M. Tuberculosis, Brazil and South Africa Multicenter Study of the Microscopic Observation for Detection and Susceptibility Test for Diagnosis of Pulmonary Tuberculosis and Tuberculosis Drug Resistance Active TB Case Finding within a Continuum of Care Package, Cambodia Hospital DOTS and Linkage Project, Indonesia Collaborative Project for the Strengthening of TB Control Strategies in Prisons, Honduras Creating a Model Multi-Drug Resistant TB Case Management System, Kazakhstan | 
