This is a randomized controlled trial being conducted under an Investigational New Drug Application from the Food and Drug Administration and co-sponsored by USAID and the National Institute of Allergies and Infectious Diseases/National Institutes of Health.
The trial is a four-arm study of alternative preventive therapy regimens for latent TB in HIV-infected adults. The study will provide important information on the most effective therapies to prevent HIV-related TB, and assess the potency of short course regimens containing rifamycins, as well as life-long therapy with isoniazid.
The preliminary estimate of the three-year TB incidence for all study arms is 15.8%, even though all patients are actively treated. Follow-up in the study will continue, and the trial will be completed in 2008.
Principal Investigator: Richard E. Chaisson (JHSPH)
Glenda Gray (Perinatal HIV Research Unit, Soweto)
James McIntyre (Perinatal HIV Research Unity, Soweto)
Neil Martinson (Co-Investigator, JHU)
Grace Barnes (Study Coordinator, JHU)
Regina Msandeware (Study Coordinator, PHRU)
Kali PB, Gray GE, Violari A, Chaisson RE, McIntyre JA, Martinson NA. Combining PMTCT with active case finding for tuberculosis. J Acquir Immune Defic Syndr. 2006 Jul;42(3):379-81.
Nachega J, Coetzee J, Adendorff T, Msandiwa R, Gray GE, McIntyre JA, Chaisson RE. Tuberculosis active case-finding in a mother-to-child HIV transmission prevention programme in Soweto, South Africa. AIDS. 2003 Jun 13;17(9):1398-400.
Nachega JB, Lehman DA, Hlatshwayo D, Mothopeng R, Chaisson RE, Karstaedt AS. HIV/AIDS and antiretroviral treatment knowledge, attitudes, beliefs, and practices in HIV-infected adults in Soweto, South Africa. J Acquir Immune Defic Syndr. 2005 Feb 1;38(2):196-201.
Nachega JB, Stein DM, Lehman DA, Hlatshwayo D, Mothopeng R, Chaisson RE, Karstaedt AS. Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa. AIDS Res Hum Retroviruses. 2004 Oct;20(10):1053-6.