PERCH Publications

PERCH has produced numerous publications detailing the rationale for the study design and analytic methods, preparatory analyses conducted to support the etiology analyses, and additional subanalyses exploring topics such as pathogen-specific results and digital auscultation of lung sounds.

Primary Results papers (submitted)
  • Clinical and microbiological findings among children with serious pneumonia from Africa and Asia: The Pneumonia Etiology Research for Child Health (PERCH) Case-Control Study
  • Aetiology of serious hospitalised pneumonia in HIV-uninfected children from Africa and Asia: Integrated Analysis of the PERCH Case-Control Study
Pneumonia Etiology Research for Child Health (PERCH): The Foundational Basis for the Primary Etiology Results

A journal supplement (June 2017, Clinical Infectious Diseases) containing 23 manuscripts, including 2 commentaries, providing background for the primary PERCH etiology analyses.  The articles fall into three categories (contextual, preparatory analyses, and methods descriptions), each of which is aimed at creating visibility into the epidemiologic and analytic thinking on PERCH, offering the lens through which challenges and opportunities were approached given what had come before in the field.

Introductory Papers

Contextualizing Papers

Methodologic Papers

Preparatory Analyses

Pneumonia Etiology Research for Child Health 2012 Methods Supplement

A journal supplement (April 2012, Clinical Infectious Diseases) containing 16 manuscripts, including 2 commentaries, providing the rationale for the epidemiologic, clinical, laboratory, and statistical design components of the study.  The papers present the key decision points and justifications for the study design, including background documentation and literature reviews that formed the basis of those decisions.  Additional papers describe issues related to the study, such as bioethical considerations for conducting pneumonia research in developing countries and an approach to post-mortem specimen collection, as well as results from two pilot pneumonia etiology studies in Kenya and New Caledonia.

Additional Publications