Measles and rubella serosurvey identifies rubella immunity gap in young adults of childbearing age in Zambia: The added value of nesting a serological survey within a post-campaign coverage evaluation survey.

Serological surveys can potentially complement vaccine coverage surveys, such as post-vaccination campaign coverage evaluation surveys (PCES), by providing direct information on population immunity within and outside the target age range of the mass vaccination campaign. In a new publication in Vaccine, the authors found that seroprevalence to measles and rubella viruses in children younger than 16  years of age was significantly higher than expected from vaccination coverage estimates, likely reflecting exposure to wild-type viruses and underreporting of vaccination.

The results of this new study conducted in the Southern Province, Zambia indicate that overall seroprevalence was 95.5% for measles virus-specific IgG and 97.7% for rubella virus-specific IgG. Rubella seroprevalence was 98.4%  among children eligible for the MR vaccination campaign, significantly higher than the reported measles-rubella (MR) vaccination campaign coverage of 89.8%, and higher than the 91.3% rubella seroprevalence for adolescents and adults 16-30  years of age.

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Measles and rubella serosurvey identifies rubella immunity gap in young adults of childbearing age in Zambia: The added value of nesting a serological survey within a post-campaign coverage evaluation survey.