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Plasma Proteomics for Nutritional Assessment


Summary

Micronutrient deficiencies affect an estimated two billion people worldwide, yet remains poorly assessed and a form of "hidden hunger" due to cost and complexity of convention biochemical assessment methods. Plasma proteomics offers an approach to detect and quantify predictive protein biomarkers of micronutrient status, inflammation and other aspects of malnutrition that, in the future, may be assayed on a single, inexpensive platform in countries where deficiencies are public health problems. This project has assessed multiple aspects of micronutrient, protein-energy, growth, dietary and aspects of functional status in a population birth cohort of 500 6-8 year old children living in the rural Southern Plains (Tarai) of Nepal. To date, suites of plasma proteins have been detected and associated with low probability of false discovery for vitamins (A, D, E, K, B6), minerals (Cu, Se), lipids (HDL, LDL, triglycerides), inflammation (AGP, CRP), growth (weight for height, height for age), body composition (arm muscle area) and cognition (general intelligence test scores). Funded by the Bill and Melinda Gates Foundation.

Dates

  • Start Date: 
    06/01/2009

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