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Cohesin complex


Summary

Cohesin is an SMC protein complex that is best known for its role in sister chromatid cohesion. There are meiosis-specific cohesin complex components that are required for homologous chromosome pairing, recombination and synapsis in addition to sister chromatid cohesion. Using mouse mutant models, together with cytological and molecular techniques, our lab has delineated the functions of the meiosis-specific subunits of cohesin. Mutations of these cohesin components are known to cause infertility and their mis-expression has been linked with poor cancer prognosis.

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