This transdisciplinary research center will improve cardiovascular outcomes and reduce racial and ethnic disparities in care in Baltimore, Maryland by using community-based participatory research principles to build strong ties among researchers, healthcare provider networks, community members, and policy-makers. We are building on prior work and established relationships with the large African American population in Baltimore, and we will initially focus on hypertension. The Center includes 3 separate but related intervention studies to improve the identification, treatment, and outcomes of African Americans with hypertension; 3 integrated and complimentary Cores; an Internal Steering Committee; and a Community and Provider Advisory Board. Study 1 is a pragmatic clinical trial that examines the implementation of a multi-method quality improvement intervention in 6 community-based primary care practices. Study 2 is a randomized controlled trial to test the effectiveness and long-term sustainability of self-management and problem-solving training for patients, family and community members. Study 3 is a 3-arm randomized controlled trial of culturally-tailored nutritional advice and a mineral supplement containing potassium, magnesium, and Vitamin C. Primary outcomes for all 3 studies are systolic and diastolic blood pressure and blood pressure control. The Administrative Core carries out the overall administration of the grant, guiding and coordinating shared resources and training activities and managing the Center’s studies. The Shared Resources Core provides infrastructure and support for study design, database development, data management and analysis, patient recruitment and retention, intervention development, standardization of measurements and dissemination of results for the Center Projects and Administrative and Training Cores. The Training Core provides transdisciplinary training and mentorship in health disparities for pre-doctoral, post-doctoral, junior faculty, and established faculty in the Schools of Medicine, Public Health, and Nursing.