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Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development


The goal of the study is to describe the impact of repeated enteric infections on growth faltering, malnutrition and delayed child development. The primary hypothesis is that specific characteristics of the infections will impair gut integrity and lead to malnutrition. This is a cohort study to be conducted in 8 countries using a harmonized protocol. Each site will follow a birth cohort of 200 children until the age of 24 months, with diarrheal surveillance, questionnaires to characterize diet, SES, child development, etc., and blood, urine and stool samples will be collected periodically to characterize micronutrient status, vaccine response, pathogen analysis. Specific tests will be done to assess child development as well. The project is led by NIH Fogarty, and Hopkins leads the Peru site. This application seeks approval to conduct the study in Peru. The other sites are Brazil, Tanzania, South Africa, Bangladesh, Nepal, Pakistan and India. There is also a companion project (Hopkins not involved in an investigatory way) that will seek to analyze saliva and/or blood samples for genetic studies. Our role here is to inform and consent for storage of the samples for such analyses.


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