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Vitamin A Supplementation of Mothers and Newborns to Reduce Risk of HIV Transmission and Mortality in Zimbabwe


Summary

Zvitambo was a 2x2 factorial, placebo-controlled, randomized trial in 14,110 pairs of mothers and newborns that assessed the efficacy of high-potency vitamin A supplementation for either or both mother and infant on infant mortality and morbidity, vertical HIV transmission, incident HIV infection, co-morbidity and mortality among mothers postpartum, as well as on plasma and breast milk viral loads. This was the largest HIV-micronutrient trial of its kind. Over the next 1½ years, while critical laboratory-based analyses proceed, several major papers are in preparation or being planned for publication on these outcomes. Though patient contact ended in 2001, several projects have and will continue to use the data for many years to come.

Dates

  • Start Date: 
    10/01/2003
  • End Date: 
    03/31/2007

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