Global Projects

Summary

Angiotensin receptor blockers (ARB) and angiotensin-converting enzyme (ACE) inhibitors are ubiquitously used to control blood pressure and urine proteinuria in the context of chronic kidney disease. While these drugs are highly effective for treating these consequences of kidney disease, it is unclear the degree to which they slow the progression of kidney damage and dysfunction. In this project we are exploring causal modelling techniques for quantifying the impact of cumulative ACE/ARB use on the time to dialysis or kidney transplant in participants of the Chronic Kidney Disease in Children (CKiD) Study