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Arsenic and immune response to influenza vaccination in pregnant women and newborns
Baltimore, MD, United States
Summary
There is a fundamental gap in understanding of whether arsenic, a known developmental toxicant, alters maternal immune responses to vaccination and whether exposure to arsenic during pregnancy impairs the transfer of maternal vaccine-induced antibody to the newborn. Moreover, factors known to affect arsenic metabolism and toxicity outcomes, particularly micronutrients critical in one-carbon metabolism, have not been evaluated in studies of arsenic immunotoxicity and vaccine-induced protection in mothers and their newborns. Continued existence of this gap represents an important problem because, until it is filled, optimal points for intervention to prevent arsenic-related immunotoxicity and morbidity during pregnancy and early life will not be known. The objective of this project is to investigate whether maternal arsenic exposure and one-carbon metabolism micronutrient deficiencies alter maternal and newborn influenza antibody titer and avidity, respiratory morbidity, and measures of systemic immune function following maternal influenza vaccination.
Project Type
Locations
- JiVitA Project Site, Bangladesh: 1 project
- Baltimore, MD, United States: 55 projects - selected city
Researchers
- Hasmot Ali
- Christopher Heaney | 3 projects
- Ruth Karron
- Sabra Klein | 2 projects
- Alain Labrique | 7 projects
- Ana Navas-Acien
- Elizabeth Ogburn
- Amanda Palmer | 5 projects
- Nora Pisanic | 2 projects
- Kerry Schulze | 5 projects
- Saijuddin Shaikh | 2 projects
- Keith West | 4 projects
- Marsha Wills-Karp | 2 projects