S-nitrosation in cell survival and cell death
Baltimore, MD, United States
Myocardial ischemia-reperfusion injury is a major cause of death among males and females in the United States, and is accompanied by a tremendous healthcare burden. Acute cardioprotective stimuli hold promise for addressing this critical issue, but few experimental discoveries have translated into effective therapeutics, possibly due to a lack of knowledge with regard to mechanistic detail. This project investigates the protective mechanism through which nitric oxide-derived protein S-nitrosation reduces ischemia-reperfusion-induced cell death in the heart, and provide potential therapeutic insight into the treatment of ischemic heart disease in males and females.
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- Baltimore, MD, United States: 47 projects - selected city