Estimating the burden of serious pneumococcal and meningococcal disease in older children and adults globally
Baltimore, MD, United States
Streptococcus pneumoniae and Neisseria meningitidis are leading causes of bacterial meningitis, sepsis, and other serious infections worldwide. Recent studies suggest an important role for vaccine-induced herd immunity as a means to prevent serious pneumococcal and meningococcal disease in unvaccinated children and adults. Thus, economic analyses that do not include herd immunity benefits of routine vaccination will underestimate the impact of the vaccine program, which may lead to delays in vaccine introduction or jeopardize the sustainability of vaccine programs after introduction.
The goal of the proposed project is to estimate the global burden of serious pneumococcal and meningococcal disease in older children and adults. Specifically, this project aims to estimate: 1. The morbidity and mortality associated with serious pneumococcal disease in older children and adults at regional and global levels, and where possible by country and syndrome. 2. The serotype distribution of serious pneumococcal disease in older children and adults globally by region. 3. The morbidity and mortality and serogroup distirbution of Neisseria meningitidis in older children and adults globally and by region.
Estimating the morbidity and mortality associated with these diseases among older children and adults is important to be able to understand the importance of pneumococcal and meningococcal disease in these populations and the potential impact of prevention and control public health interventions such as pediatric vaccination. This project will provide epidemiologic and cost effectiveness data to policy-makers to strengthen the evidence base for national and international investment in pneumococcal and meningococcal vaccines.
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