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Evaluation of the Binax NOW S. pneumoniae test for use in blood of pneumonia patients in low- and middle-income countries

Bamako, Mali


Summary

Detection of pneumococcal pneumonia and sepsis in low- and middle-income countries is limited by the poor sensitivity of blood culture, the existing “gold standard” diagnostic method. The objective of this project is to evaluate whether the Binax NOW® Immuno-Chromatographic Test and real-time Polymerase Chain Reaction for the pneumococcal LytA gene can enhance the diagnosis of pneumococcal pneumonia and sepsis, improve incidence estimates, and facilitate evaluation of pneumococcal vaccines in these settings. In addition, multiplex PCR testing for pneumococcal capsular serotypes will provide valuable data on the serotype distribution of blood culture-positive and culture-negative cases of pneumococcal pneumonia and sepsis.

Dates

  • Start Date: 
    01/01/2009
  • End Date: 
    06/30/2011

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