Parental lifetime occupational exposures and risk of autism spectrum disorder in offspring
Autism spectrum disorder (ASD) may be the consequence of genetic susceptibility triggered by environmental insult through in utero or postnatal exposures from mothers or male-mediated pathways for developmental impact via paternal exposures. I propose to integrate job exposure matrices into population-based surveillance data to investigate associations between lifetime parental occupational exposures and risk of ASD in offspring, then examine gene-environment interaction with polygenic risk scores for ASD. This research will enable an unprecedented assessment of sources of parent-specific exposures, potential mechanisms of impact, and novel gene-environment interaction in exposure risk assessment for neurodevelopmental outcomes.
- Start Date:
- End Date:
- Copenhagen, Denmark: 3 projects - selected city