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A Multi-center Study of the MODS Test for Diagnosis of Pulmonary TB and TB Drug Resistance, Brazil

Brasilia, Brazil


Summary

The increase in drug resistant tuberculosis (TB) threatens the success of global TB control. There is an urgent need for inexpensive, accurate methods for detection of M. tuberculosis in clinical specimens and for drug susceptibility testing. An inexpensive, efficient liquid-culture method (“microscopic observation for detection and susceptibility” or MODS) that relies on microscopic detection of early mycobacterial growth was developed by Robert Gilman and validated in our laboratory for isoniazid and rifampin drug-susceptibility testing. The performance of this test has not yet been evaluated in a large, prospective study under field conditions in the setting of a developing/transitional country.

The overall goal of this project is to prospectively evaluate the performance of MODS for detection of M. tuberculosis and M. tuberculosis drug susceptibility in respiratory specimens obtained from persons undergoing evaluation for pulmonary TB in Rio de Janeiro, Brazil.

Dates

  • Start Date: 
    10/01/2004
  • End Date: 
    09/30/2006

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