Shyam S. Biswal
Shyam S. Biswal

Shyam S. Biswal, PhD

  • Professor

Departmental Affiliations

  • Environmental Health and Engineering (Primary)
  • School of Medicine (Joint)

Center & Institute Affiliations

  • Center for Global Health

Contact Information

E: sbiswal@jhu.edu

Research Program - learn more in this link: http://ehe.jhu.edu/research/faculty-research-interests/biswal/index.html
PhD Program Track -Toxicology, Physiology, & Molecular Mechanisms: http://ehe.jhu.edu/graduate/doctoral-programs/doctor-of-philosophy-in-environmental-health-sciences/track-in-toxicology-physiology-and-molecular-mechanisms/index.html


Education

PhD, Indian Institute of Technology, 1996
MS, Nagpur University

Overview

See details in Research Program page

http://ehe.jhu.edu/research/faculty-research-interests/biswal/index.html

Research Interests

  • Environmental Health Sciences
  • Electronic Cigarettes
  • Cigarette Smoke
  • Lung diseases
  • Inflammation
  • Cancer
  • COPD
  • Emphysema
  • Asthma

Publications

Selected publications

  • Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, Herman JG, Baylin SB, Sidransky D, Gabrielson E, Brock MV, Biswal S. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.┬áPLoS medicine. 2006; 3(10):e420.
  • Kim JH, Thimmulappa RK, Kumar K, Cui W, Kumar S, Kombairaju P, Gaiano N, Zhang H, Margolick J, Matsui W, Macvittie T, Malhotra SV, Biswal S. NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation. J Clin Invest. 2014;3;124(2):730-41.
  • Singh A, Happel C, Manna SK, Acquaah-Mensah G, Carrerero J, Kumar S, Nasipuri P, Wakabayashi N, Dewi R, Boros LG, Gonzalez FJ, Gabrielson E, Wong KK, Girnun G, Biswal S. Nrf2 regulates miR-1 and miR-206 to drive Tumorigenesis. J Clin Invest. 2013;123 (7) 2921-2934.
  • Mizumura K, An CH, Shan B, Franks JM, Haley KJ, Owen CA, Tesfaigzi Y, Washko GR, Quackenbush J, Silverman EK, Rahman I, Kim HP, Mahmood A, Biswal SS, Ryter SW, Choi AM. Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest. 2013;123(12):5212-30.
  • Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, Sathirapongsasuti JF, Cervo M, Yao H, Chung AL, Harvey C, Thimmulappa R, Sethi S, Kong X, Yarmus L, Brown R, Feller-Kopman D, Wise R, and Biswal S. (2011) Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model. Sci Transl Med 3(78):78ra32.