Shengzhang Dong
Shengzhang Dong

Shengzhang Dong, PhD

  • Research Associate

Departmental Affiliations

  • Molecular Microbiology and Immunology (Primary)

Contact Information

615 N. Wolfe Street
Room E3410
Baltimore, Maryland 21205

P:  410-955-3223
E: sdong13@jhu.edu


Education

PhD, Zhejiang University, 2007
BS, Anhui Agricultural University, 2001

Overview

Mosquito vectors transmit a broad range of human viral and parasitic diseases and over one million people worldwide die from mosquito-borne diseases every year. Current measures to control arthropod-borne diseases and their mosquito vectors are insufficient partially due to the lack of sustainable vector control strategies and vaccines. The overall goal of my research interests is to study the molecular biology and genomics of mosquitoes and mosquito-pathogen interactions, leading to the development of novel control strategies for vector-borne diseases.

Research Interests

  • Zika virus
  • Dengue virus
  • Chikungunya virus
  • Plasmodium
  • CRISPR/Cas9
  • Aedes aegypti
  • Anopheles gambiae

Publications

Selected publications

  • Dong S, Kang S, Dimopoulos G, 2019. Identification of anti-flaviviral drugs with mosquitocidal and Zika virus transmission-blocking activity in Aedes aegypti. PloS Neglected Tropical Diseases, 13:e0007681.
  • Dong S, Balaraman V, Kantor AM, Lin J, Grant DG, Held NL, Franz AWE, 2017. Chikungunya virus dissemination from the midgut of Aedes aegypti is associated with temporal basal lamina degradation during bloodmeal digestion. PloS Neglected Tropical Diseases, 11:e0005976.
  • Dong S, Kantor AM, Lin J, Held NL, Clem RJ, Passarelli AL, Franz AWE, 2016. Infection pattern and transmission potential of chikungunya virus in two New World laboratory-adapted Aedes aegypti strains. Scientific Report, 6:24729.
  • Dong S, Lin J, Held NL, Clem RJ, Passarelli AL, Franz AWE, 2015. Heritable CRISPR/Cas9-Mediated Genome Editing in the Yellow Fever Mosquito, Aedes aegypti. PLoS ONE, 10 (3): e0122353.
  • Dong S, Ye G, Zhu J, Chen Z, Hu C, Liu S, 2007.Vitellin of Pteromalus puparum (Hymenoptera: Pteromalidae), a pupal endoparasitoid of Pieris rapae (Lepidoptera: Pieridae): biochemical characterization, temporal patterns of production and degradation. Journal of Insect Physiology, 53: 468-477.