Anne Hamacher-Brady
Anne Hamacher-Brady

Anne Hamacher-Brady, PhD

  • Assistant Professor

Departmental Affiliations

  • Molecular Microbiology and Immunology (Primary)
  • Biochemistry and Molecular Biology (Joint)

Contact Information

615 N. Wolfe Street
Room E5642
Baltimore, Maryland 21205

E: abrady9@jhu.edu

ResearchGate profile: https://www.researchgate.net/profile/Anne_Hamacher-Brady
Google Scholar: https://scholar.google.com/citations?user=gh4gGRsAAAAJ&hl=en
LinkedIn: https://www.linkedin.com/in/anne-hamacher-brady-58604967/


Education

PhD, RWTH Aachen University, 2006
MSc, RWTH Aachen University, 2003

Overview

Research in my laboratory is focused on the understanding of molecular mechanisms that regulate the mitochondrial contribution to programmed cell death and inflammation signaling. Both processes are fundamental to a variety of diseases, including cancer, neurodegeneration and infectious diseases. In this context we are specifically interested in mitochondrial autophagy and interorganellar interactions, including with the endolysosomal compartment. We are applying a combination of fluorescence microscopy, molecular and cell biological, and biochemical approaches. Our studies aim at uncovering novel cell biological insights that can be exploited to combat diseases.

Research Interests

  • Lysosomal degradative pathways, incl. autophagy and endolysosomal signaling
  • Autophagy receptors, incl. Bnip3- and Nix-mediated mitophagy
  • Programmed cell death, incl. apoptosis, ferroptosis, necroptosis
  • Inflammation
  • Ubiquitin and E3 ligases
  • Role of mitochondria and mitophagy in cell death and innate immunity
  • Cell biology
  • Cancer, Neurodegeneration, Host cell responses to intracellular pathogens (Listeria, Shigella, Plasmodium)

Publications

Recent publications:

  • Hamacher-Brady, A.* and Brady, N.R.* “Mitophagy Programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.”  Cell Mol Life Sci. 2016 Feb;73(4):775-95. doi: 10.1007/s00018-015-2087-8. Epub 2015 Nov 26. Review. *Communicating authors
  • Hamacher-Brady, A.*, Brady, N.R.* “Bax/Bak-dependent, Drp1-independent targeting of XIAP into inner-mitochondrial compartments counteracts Smac-dependent effector caspase activation.” J Biol Chem. 2015 July 1. doi:10.1074/jbc.M115.643064  *Communicating authors
  • Eling, N., Reuter, L., Hazin, J., Hamacher-Brady, A.*, and N.R. Brady* “Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells.” Oncoscience. 2015 May 2  *Communicating authors
  • Metz, P., Chiramel, A., Chatel-Chaix, L., Alvisi, G., Bankhead, P., Mora-Rodriguez, R., Long, G., Hamacher-Brady, A., Brady, N.R., and R. Bartenschlager “Dengue virus inhibition of autophagic flux and dependency of viral replication on proteasomal degradation of the autophagy receptor p62.” J Virol. 2015 May 27. pii: JVI.00787-15.
  • Hamacher-Brady, A.*, Choe, S.C., Krijnse-Locker, J., and N.R. Brady* “Intra-mitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase.” Cell Death Differ. 2014 Aug 1.  *Communicating authors