Philip Jordan
Philip Jordan

Philip Jordan, PhD

  • Associate Professor

Departmental Affiliations

  • Biochemistry and Molecular Biology (Primary)
  • School of Medicine (Joint)

Contact Information

615 N. Wolfe Street
Room E8626
Baltimore, Maryland 21205

P:  410-614-4773
F:  +1 (410) 955 2926
E: pjordan8@jhu.edu

Jordan Lab website: http://www.jordanlab.space


Education

PhD, University of Edinburgh, 2006
BS, Flinders University of South Australia, 2001

Overview

Research in the Jordan laboratory focuses on understanding the molecular mechanisms regulating DNA repair, chromosome segregation and cell cycle progression. Their lab studies the importance of Structural Maintenance of Chromosomes (SMC) complexes and cell cycle kinases, particularly Polo-like (PLK) kinases and Aurora kinases. The Jordan lab uuse mouse as a model organism to study consequences of gene mutation and chromosome missegregation, which give rise to physical and mental developmental defects, infertility and cancer predisposition. They also use mouse and human pluripotent stem cells to help define the function of these proteins within essential molecular pathways of the cell.

Current research from the Jordan laboratory encompasses the following:

1) Gametogenesis (spermatogenesis and oogenesis)

2) Pluripotent stem cell preservation, proliferation, and differentiation

3) Neurodevelopment

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CURRENT LAB MEMBERS:

Philip Jordan - Principle Investigator

Marina Pryzhkova - Postdoctoral researcher

Grace Hwang - 5th year PhD student

Jessica Hopkins - 4th year PhD student

Stephen Wellard - 3rd year PhD student

Zach Perdun - ScM Masters student

Javaughn Gray - MHS Research student

Maria Laura Reategui - MHS Research student

Xueqi Zhao - MHS Research student

GRADUATED STUDENTS:

Ayobami Ward - ScM Masters student - 2015

Himaja Gaddipati - ScM Masters student - 2015

Miebaka Jamabo - ScM Masters student - 2016

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Honors and honors

2017: R21 NIH Research Grant, ORIP

2016: R01 NIH Research Grant, NIGMS

2015: Johns Hopkins Discovery Award

2014: Ho-Ching Yang Memorial Faculty Fellowship in Cancer Prevention

2013: R00 NIH Pathway to Independence Award, NICHD

2011: K99 NIH Pathway to Independence Award, NICHD

2010: US-UK Fulbright Distinguished Scholar Award, US-UK Fulbright Commission

2006: Federation of European Biochemical Societies Research Award

2005: Society for General Microbiology President’s Research Award and post-funding prize

2005: European Unions’ ERASMUS Student Mobility Award

2004: British Council - Austrian Academic Research Collaboration Award

2002: Darwin Trust International PhD Scholarship, University of Edinburgh, Scotland

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Research Interests

  • Genome maintenance
  • Meiosis
  • Embryonic stem cells
  • DNA recombination
  • Chromosome segregation
  • Structural Maintenance of Chromosomes (SMC)
  • SMC5/6
  • Cohesin, Condensin
  • Synaptonemal complex
  • Polo-like kinase (PLK)
  • Aurora kinase (AURK)

Publications

>

  • > Jordan P, Klein F, Leach D, (2007), Novel roles for selected genes in meiotic DNA processing. PLoS Genetics, 12:e222.

    > Jordan P, Copsey A, Newnham L, Kolar E, Lichten M and Hoffmann E, (2009), Ipl1/Aurora B kinase coordinates synaptonemal complex disassembly with cell cycle progression and crossover formation in budding yeast meiosis. Genes and Development, 23 (18):2237-2251.

    > Newnham L, Jordan P, Rockmill B, Roeder S and Hoffmann E, (2010), The synaptonemal complex protein, Zip1, promotes the segregation of nonexchange chromosomes at meiosis I. Proceedings of the National Academy of Sciences, 107 (2):781-785.

    > Jordan P, Karpinnen J and Handel MA, (2012), Polo-like kinase is required for synaptonemal complex disassembly in mouse spermatocytes. Journal of Cell Science, 125:5061-5072.

    > Gómez R*, Jordan P*, Viera A, Alsheimer M, Fukuda T, Jessberger R, Llano E, Pendás A, Handel MA and Suja J, (2013), Dynamic localization of SMC5/6 complex proteins during mammalian meiosis and mitosis implies functions in distinct chromosome processes. Journal of Cell Science, 126:4239-4252.

    * Authors contributed equally to this work

    > Copsey A*, Tang S*, Jordan P* , Blitzblau H, Sonya Newcombe S, Andrew Chi-ho Chan A, Newnham L, Li Z, Gray S, Herbert A, Arumugam P, Hochwagen A, Hunter N, and Hoffmann E, (2013), Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions. PLoS Genetics, 9: e1004071

    * Authors contributed equally to this work

    > Newnham L*, Jordan P*, Carballo J, Newcombe S and Hoffmann E, (2013), Ipl1/Aurora kinase suppresses S-CDK-driven spindle formation during prophase to ensure chromosome integrity during meiosis. PLoS One, 8: e83982

    * Authors contributed equally to this work

    > Hopkins J, Hwang G*, Jacob J*, Sapp N*, Bedigian R, Oka K, Overbeek P, Murray S and Jordan P, (2014), Meiosis-specific cohesin component, Stag3 is essential for mediating recombination and synapsis between homologous chromosomes and maintaining sister chromatid cohesion. PLoS Genetics, e1004413.

    * Authors contributed equally to this work

    > Verver D, Langedijk N, Jordan P, Repping S and Hamer G, (2014), The Smc5/6 complex is involved in crucial processes during human spermatogenesis. Biology of Reproproduction, 91:22.

    > Verver D.E*., Hwang G.*, Jordan P.# and Hamer G.#, (2015), Resolving complex chromosome structures during meiosis: versatile deployment of Smc5/6, Chromosoma, 125 (1) 15-27.

    * Authors contributed equally to this work

    # corresponding authors

    > Fu C, Begum K, Jordan PW, He Y and Overbeek P, (2016), Dearth and Delayed Maturation of Testicular Germ Cells in Fanconi Anemia E Mutant Male Mice PLoS One. In Press

    > Pryzhkova M.V. and Jordan P.W., (2016), Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression, Journal of Cell Science, 129: 1619-1634.

    > Ward A., Hopkins J., Mckay M., Murray S. and Jordan P.W., (2016), Genetic interactions between the meiosis-specific cohesin components, STAG3, REC8 and RAD21L, G3: Genes, Genomes and Genetics, 6:1713-1724.

    > Jordan PW, Eyster C, Chen J, Pezza RJ and Rankin S. (2017) Sororin is enriched at the central region of synapsed meiotic chromosomes. Chromosome Research. In Press.

    > Hwang G, O’Brien M, Sun F, Eppig J, Handel MA, Jordan PW (2017) SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Development. 144: 1648-1660.