615 N. Wolfe Street
Baltimore, Maryland 21205
F: (410) 955-0105
PhD, Johns Hopkins University, 1998
MA, University of Georgia, 1996
MS, University of Georgia, 1994
BA, Randolph-Macon College, 1992
The overarching goal of my research program is to uncover the mechanisms mediating how males and females differ in their immune responses to viral infection and vaccination. We hypothesize that sex steroids and signaling through sex steroid receptors are critical pathways modulating immune responses to viruses. We consider how immunological, hormonal, and genetic differences between males and females affect sex differences in susceptibility to viruses, including influenza viruses. Our research indicates that females typically mount more robust immune responses than males, which can be beneficial for clearance of viruses, but also can be detrimental by causing immunopathology. Lastly, we study the mechanisms mediating altered immune responses and infectious disease pathogenesis during pregnancy, which also involves sex steroids.
2016 Distinguished Alumni Award, Randolph-Macon College
2010 Society for Women’s Health Research Medtronic Award for Science Contributions
2007 Johns Hopkins Bloomberg School of Public Health Faculty Innovation Fund Award
2002 National Foundation for Infectious Diseases New Investigator Award
This list contains recent publications from the past year, with a majority reflecting the hard work of trainees in the Klein lab.