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Janet Holbrook, PhD

  • Professor

Departmental Affiliations

  • Epidemiology (Primary)
    • Division: Clinical Trials and Evidence Synthesis

Center & Institute Affiliations

Contact Information

415 N. Washington Street
2nd Floor
Baltimore, Maryland 21231


View Current Courses


PhD, Johns Hopkins University, 1999
MPH, University of California, Berkeley, 1987
MS, University of Maryland, 1983
BA, University of Maryland, 1980


My primary interest is in the design, conduct, and analysis of multicenter clinical trials.  Many of the trials we have completed are comparative effectiveness trials - head to head comparisons of competing treatment with patient-centered outcomes. Most of my experience has been in trials in ophthalmology and pulmonology (seeing and breathing!). I teach two classes on clinical trials at the School. We also offer an abbreviated course on Coursera.

A full list of my published public citations can be found at My Bibliography (you may have to copy link into browser:

  • Epidemiology
  • randomized clinical trials
  • multicenter studies
  • asthma
  • uveitis
  • COPD
  • Holbrook JT, Wise RA, Gold BD, Blake K, Brown ED, Castro M, Dozor AJ, Lima JJ, Mastronarde JG, Sockrider MM, Teague WG.  Lansoprazole for children with poorly controlled asthma: a randomized clinical trial.  in Children with Asthma.  JAMA 2012; 307(4): 1-9.

  • Holbrook JT, Kempen JH, Prusakowski NA, Altawel MM, Jabs DA.  Challenges in the design and implementation of The Multicenter Uveitis Steroid Treatment (MUST) Trial – Lessons for Comparative Effectiveness Trials.  Clinical Trials 2011;8(6):736-743.

  • Kempen JH, Altaweel MM, Holbrook JT, Jabs DA, Louis TA, Sugar EA, Thorne JE. Randomized comparison of systemic anti-inflammatory therapy versus flucinolone actinide intraocular implant for intermeadiate, posterior and panuveitis: The Multicenter Uveitis Treatment Trial.  Ophthalmology 2011;118(10):736-743.

  • Holbrook JT, Colvin R, Van Natta ML, Thorne JE, Bardsley M, Jabs DA.  Evaluation of the United States Public Health Service guidelines for discontinuation of anti-CMV therapy after immune recovery in patients with CMV retinitis.  Am J Ophthalmology 2011;142(4):628-637.

  • Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group. The MUST Trial: rational, design and baseline characteristics. 2010;149:550-561.