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Maria Deloria Knoll, PhD

  • Senior Scientist

Departmental Affiliations

Center & Institute Affiliations

Contact Information

415 N. Washington Street
Room 549
Baltimore, Maryland 21231

410-736-8241
443-287-6714

IVAC Homepage
View-hub - Vaccine Information and Epidemiology Window
PERCH 7-country pneumonia etiology case-control study

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Education

PhD, Johns Hopkins University, 2000
BS, University of North Carolina, Chapel Hill, 1987

Overview

As the Director of Epidemiology for IVAC (International Vaccine Access Center), focus on the technical analytical challenges of policy-driven research pertaining to the design, conduct and analysis of epidemiological studies and clinical trials that evaluate vaccines and vaccine-preventable diseases. I direct the analysis of a 7-country pneumonia case-control study (PERCH) to determine the causes of pneumonia in developing country settings to guide the development of new pneumonia vaccines and treatment algorithms. Multiple projects have involved evaluating the impact of pneumococcal conjugate vaccine introduction into national immunization programs in India, Nepal, Kenya and The Gambia on pneumococcal disease, and in global assessments of its impact. I also have an interest in evaluating new diagnostic tools such as antigen-based blood tests and pneumococcal serotype-specific urine antigen tests for sensitivity and specificity of disease detection in pneumonia patients, and digital tools to assist in the standardization of clinical findings, such as digital auscultation and computer automated chest x-ray interpretation. I also work on collaborative efforts with other Departments and Institutions to develop new analytical tools, such as an analytical method for estimating pneumonia etiology. Secondary data analysis projects include global meta-analytical projects to estimate disease burden and vaccine impact, such as estimating the burden and serotype distribution of pneumococcal, Hib and meningococcal disease among children and adults, and evaluation of pneumococcal conjugate vaccine schedules and products to inform country decision-making regarding these programmatic choices.

Honors and Awards

National Institutes of Health Merit Award (1999,1991)

Food and Drug Administration Commissioner’s Special Citation Group Award (1997)

U.S. DHHS Secretary’s Group Award for Distinguished Service (1996)

U.S. DHHS Special Achievement Award (1995,1991)

  • vaccines
  • international health
  • S. Pneumoniae
  • H. influenzae
  • RSV
  • meningococcus
  • HPV
  • pertussis
  • pneumonia
  • vaccine preventable diseases
  • epidemiology
  • clinical trials
  • meta-analysis
  • etiology estimation
  • disease burden
  • vaccine impact
  • pneumococcal conjugate vaccine

Selected representative publications:

  • Deloria Knoll M, Fu W, Shi Q, Prosperi C, Wu Z, Hammitt LL, Feikin DR, Baggett HC, Howie SRC, Scott JAG, Murdoch DR, Madhi SA, Thea DM, Brooks WA, Kotloff KL, Li M, Park DE, Lin W, Levine OS, O’Brien KL, Zeger SL. Bayesian estimation of pneumonia etiology: epidemiologic considerations and applications to pneumonia etiology research for child health study. Clin Infect Dis 2017; 64(suppl 3):S213–27.
  • Deloria Knoll M, Morpeth SC*, Scott JAG, Watson NL, Park DE, Baggett HC, Brooks WA, Feikin DR, Hammitt LL, Howie SRC, Kotloff KL, Levine OS, O’Brien KL, Thea DM, Ahmed D, Antonio M, Awori JO, Baillie VL, Chipeta J, Deluca AN, Dione M, Driscoll AJ, Higdon MM, Jatapai A, Karron RA, Mazumder R, Moore DP, Mwansa J, Nyongesa S, Prosperi C, Seidenberg P, Siludjai D, Sow SO, Tamboura B, Zeger SL, Murdoch DR, Madhi SA, PERCH Study Group. Evaluation of pneumococcal load in blood by PCR for the diagnosis of pneumococcal pneumonia in young children in The Pneumonia Etiology Research for Child Health (PERCH) study. Clin Infect Dis 2017; 64(suppl 3):S357–67. *co-first author
  • Deloria Knoll M, Park DE, Johnson TS, Chandir S, Nonyane BA, Conklin L, Fleming-Dutra KE, Loo JD, Goldblatt D, Whitney CG, O'Brien KL. Systematic review of the effect of pneumococcal conjugate vaccine dosing schedules on immunogenicity. Pediatr Infect Dis J 2014;33 (Suppl 2):S119-29.
  • Wahl B, O’Brien KL, Greenbaum A, Liu L, Chu Y, Majumder A, Lukši? I, Nair H, McAllister DA, Campbell H, Rudan I, Black R, Knoll MD. Global, regional, and national burden of Streptococcus pneumoniae and Haemophilus influenzae type b in children in the era of conjugate vaccines: updated estimates from 2000-2015. Lancet Global Health 2018; 6: e744–e757.
  • Johnson HL, Deloria-Knoll M, Levine OS, Freimanis L, Reithinger R, Muenz L, O'Brien KL. Systematic Evaluation of Serotypes Causing Invasive Pneumococcal Disease among Children Under Five: The Pneumococcal Global Serotype Project. PLoS Med 2010; 7(10): e1000348. doi:10.1371/journal.pmed.1000348.