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David Sack, MD

  • Professor

Departmental Affiliations

Center & Institute Affiliations

Contact Information

615 N. Wolfe Street
Room 5537
Baltimore, Maryland 21205

443-287-8795
410-502-6733

Stop cholera
List of publications

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Education

MD, University of Oregon, 1969

Overview

David Sack, M.D., is a Professor of Internal Health at the Bloomberg School of Public Health with a joint appointments in the Department of Epidemiology and Infectious Diseases, Johns Hopkins University. Dr. Sack’s research has been focused on enteric infections and vaccine development for these infections. With regard to enteric infections, this has included laboratory detection of these agents, describing their epidemiology in developing country populations and travelers developing appropriate clinical management strategies including antibiotics and rehydration methods.

With regard to vaccines, Dr. Sack has participated in the development of vaccines for cholera, rotavirus, enterotoxigenic E coli (ETEC), and shigellosis. Currently, he leads a large project called the DOVE project (Delivering Oral Cholera Vaccine Effectively). Working in collaboration with UNICEF, WHO and other partners, this project facilitates the use oral cholera vaccine as part of an integrated strategy for cholera control. A web site providing details on the use of oral cholera vaccine is at www.stopcholera.org.

To develop vaccines for ETEC, Dr. Sack collaborates with scientists at Kansas State University on a new approach, called MEFA (muti-epitope fusion antigens) to provide broad protection against these bacterial infections by targeting the many colonization factors and toxin antigens with a single fusion protein. The MEFA vaccine is now in the preclinical phase but soon will begin clinical trials.

Honors and Awards

Gates Award for Global Health for the ICDDRB

Independence Day Award for the ICDDRB

  • International Health
  • cholera
  • cholera vaccine
  • Cameroon
  • rotavirus
  • diarrhea
  • Bangladesh
  • Gates Award
  • enterotoxigenic Escherichia coli
  • shigella
  • shigellosis
  • typhoid
  • International Center
  • epidemiology
  • oral rehydration solution
  • ORS
  • malaria
  • tuberculosis
  • stopcholera
  • Shanchol
  • Euvichol
  • Vibrio.

Selected publications from last 4 years.

  • Ruan X, Sack DA, Zhang W. Genetic Fusions of a CFA/I/II/IV MEFA (Multiepitope Fusion Antigen) and a Toxoid Fusion of Heat-Stable Toxin (STa) and Heat-Labile Toxin (LT) of Enterotoxigenic Escherichia coli (ETEC) Retain Broad Anti-CFA and Antitoxin Antigenicity. PLoS One 2015; 10(3): e0121623
  • Ali M, Nelson AR, Lopez AL, Sack DA. Updated global burden of cholera in endemic countries. PLoS Negl Trop Dis 2015;9:e0003832.
  • Debes AK, Ateudjieu J, Guenou E, Ebile W, Sonkoua IT, Njimbia AC, Steinwald P, Ram M, Sack DA, 2016. Clinical and Environmental Surveillance for Vibrio cholerae in Resource Constrained Areas: Application During a 1-Year Surveillance in the Far North Region of Cameroon. Am J Trop Med Hyg 94: 537-43.
  • Sack, DA. A new era in the history of cholera: the road to elimination. International Journal of Epidemiology 2013;42:1537–1540.
  • George CM, Monira S, Sack DA, Rashid MU, Saif-Ur-Rahman KM, Mahmud T, et al. Randomized Controlled Trial of Hospital-Based Hygiene and Water Treatment Intervention (CHoBI7) to Reduce Cholera. Emerg Infect Dis. 2016;22(2):233-41.