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Adrienne Tin, PhD

  • Assistant Scientist

Departmental Affiliations

Center & Institute Affiliations

Contact Information

615 N. Wolfe Street
Room W6017
Baltimore, Maryland 21205

443-287-4740

View Current Courses

Education

PhD, Johns Hopkins Bloomberg School of Public Health, 2012
MS, New Jersey Institute of Technology, 2004

Overview

Dr. Tin’s research focuses on increasing our understanding on the genetic and non-genetic susceptibility for chronic kidney disease (CKD) and related traits and to identify novel targets for prevention and treatment. Chronic diseases are consequences of genetic susceptibility and environmental exposure. Dr. Tin uses a multilevel approach that combines genomic information (DNA sequence variation, DNA methylation, and gene expression) with clinical and metabolomics information from population-based studies. This integrated approach can identify intermediaries that are at the intersection of genetic susceptibility and environmental exposure and link the biological pathways in the pathogenesis of a disease.

Honors and Awards

New Jersey Institute of Technology M.S. Program in Applied Statistics Assistantship, 2003.

Executive Women of New Jersey Graduate Merit Award, 2004.

The Inaugural W.H. Linda Kao Collaboration Award, 2014

  • Chronic kidney disease
  • Gout
  • Serum Urate
  • GSTM1
  • metabolomics

Most recent first-authored publications

  • Tin A, Grams ME, Estrella M, Lipkowitz M, Greene TH, Kao WH, et al. Patterns of Kidney Function Decline Associated with APOL1 Genotypes: Results from AASK. Clin J Am Soc Nephrol. 2016 May 26. PubMed PMID: 27230965. Epub 2016/05/28. Eng.
  • Tin A, Grams ME, Ashar FN, Lane JA, Rosenberg AZ, Grove ML, et al. Association between Mitochondrial DNA Copy Number in Peripheral Blood and Incident CKD in the Atherosclerosis Risk in Communities Study. J Am Soc Nephrol. 2016 Jan 21. PubMed PMID: 26794963. Epub 2016/01/23. Eng.
  • Tin A, Balakrishnan P, Beaty TH, Boerwinkle E, Hoogeveen R, Youn JH, et al. GCKR and PPP1R3B Identified as Genome-wide Significant Loci for Plasma Lactate: the Atherosclerosis Risk in Communities (ARIC) Study. Diabet Med. 2015 Oct 3. PubMed PMID: 26433129. Epub 2015/10/04. Eng.
  • Tin, A, Kottgen, A, folsom, A, maruthur, NM, Nalls, M, evans, AM, Zonderman, A, Friedrich, N, boerwinckle, E, Coresh, J, Kao, L: Genetic Loci for Serum Magnesium among African-Americans and Gene-Environment Interaction at MUC1 and TRPM6 in European-Americans: the Atherosclerosis Risk in Communities (ARIC) Study. BMC Genet. 2015;16:56. PubMed PMID: 26058915. Pubmed Central PMCID: 4462077. Epub 2015/06/11. eng.
  • Tin A, Grams ME, Maruthur NM, Astor BC, Couper D, Mosley TH, et al. Hemostatic Factors, APOL1 Risk Variants, and the Risk of End-Stage Renal Disease in the Atherosclerosis Risk in Communities Study. Clin J Am Soc Nephrol. 2015 Apr 17. PubMed PMID: 25887069. Epub 2015/04/19. Eng.