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Colleen F. Hanrahan, PhD

  • Assistant Scientist

Departmental Affiliations

  • Epidemiology (Primary)
    • Division: Infectious Disease Epidemiology

Center & Institute Affiliations

Contact Information

615 N. Wolfe Street
Room E6031
Baltimore, Maryland 21205

410-502-9289

View Current Courses

Education

PhD, Johns Hopkins Bloomberg School of Public Health, 2011
MS, Clemson University, 1998

Overview

The main focus of my research is on understanding the impact of interventions to control tuberculosis, particularly within the context of the HIV pandemic. TB is largely a story of implementation failures. We have good tools for prevention, treatment and diagnosis, but their implementation is sub-optimal in ways that result in a reduction or absence of impact on individual and population-level health. As new tools become available during the current exciting era of TB research, my goal is to understand, refine and improve the implementation of these tools (and existing ones) in order to significantly bend the curve of the epidemic.

In particular, I am interested in using operational research to examine the impact and appropriate implementation of both new and existing diagnostic tests, active or intensified case finding strategies, new and existing preventive therapy regimens, and health systems-level interventions to retain patients in the cascade of TB care.  I am also interested in the impact of local, national and international TB control policies on TB epidemiology.  I employ a mix of standard epidemiologic methods as well as implementation science, stated preference methods (e.g discrete choice experiments) and economic evaluation in my work.

A secondary research interest area is evaluating the effect of differentiated care strategies on retention in care for people living with HIV in high burden settings. These strategies offer care that is tailored towards the needs of specific populations in order to achieve long term virologic suppression and favorable clinical outcomes. Interventions include medication adherence clubs, fast tracks and community ART pickup points.

Most of my research is in South Africa, where I have worked for over a decade.

  • tuberculosis
  • hiv
  • diagnostic testing
  • implementation science
  • active case finding
  • preventive therapy
  • stated preference methods

5 of my most recent first author/senior author papers:

  • Maternal Motivation to Take Preventive Therapy in Antepartum and Postpartum Among HIV-Positive Pregnant Women in South Africa: A Choice Experiment. Kim HY, Dowdy DW, Martinson NA, Kerrigan D, Tudor C, Golub J, Bridges JFP, Hanrahan CF. AIDS and behavior. 2018
  • Diagnostic strategies for childhood tuberculosis in the context of primary care in a high-burden setting: the value of alternative sampling methods. Hanrahan CF, Dansey H, Mutunga L, France H, Omar SV, Ismail N, Bassett J, Van Rie A. Paediatrics and international child health. 2018; :1-7.
  • Chest X-ray for tuberculosis preventive therapy: use caution. Hanrahan C, Dowdy D. The lancet. HIV. 2018; 5(9):e478-e479.
  • Maternal priorities for preventive therapy among HIV-positive pregnant women before and after delivery in South Africa: a best-worst scaling survey. Kim HY, Dowdy DW, Martinson NA, E Golub J, Bridges JFP, Hanrahan CF. Journal of the International AIDS Society. 2018; 21(7):e25143.
  • A proposed novel framework for monitoring and evaluation of the cascade of HIV-associated TB care at the health facility level. Hanrahan CF, Van Rie A. Journal of the International AIDS Society. 2017; 20(1):21375.