MD, Yale University School of Medicine, 1992
Our lab investigates the host genetics and host response to chronic viral hepatitis infections including hepatitis B virus (HBV) and hepatitis C virus (HCV) in people with and without co-infection with HIV. For both of these viruses, some individuals can recover from the infection (with HCV they clear it but with HBV they suppress replication without medications) and some individuals have a chronic infection. Our overall goal for the HBV studies is to understand the immune response to HBV to aid in the development of a cure. Current studies include: 1) HBV virology in single hepatocytes from liver tissue obtained through laser capture microscopy, 2) T and B cell immune response to people acutely infected with HBV, 3) Developing a neutralizing antibody assay to study the antibody response to HBV, and 4) Using genome wide association stud (GWAS) data to find human genetic variants that are associated with HBV recovery or persistence. For our HCV studies we also use GWAS data to find host genetic variants associated with clearance or persistence. We are also looking at how HIV therapy alters the immune response to HCV in those with HIV-HCV co-infection.
Honors and Awards
Phi Beta Kappa, 1987
Recipient, Burroughs Wellcome Fund Pathogenesis in Infectious Diseases Award, 2000
Interurban Clinical Club, 2011
American Society of Clinical Investigation, 2008
Selected Publications from the last 5 years
- Duggal P, Thio CL, Wojcik GL, Goedert JJ, Mangia A, Latanich R, Kim AY, Lauer GM, Chung RT, Peters MG, Kirk GD, Mehta S, Cox AL, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Tobler LH, Busch MP, Alexander G, Rosen HR, Gao X, Abdel-Hamid M, Apps R, Carrington M, Thomas DL. Genome wide association study of spontaneous resolution of hepatitis c virus. Annals of Internal Medicine, 2013, Feb 19;158(4):235-45.
- Seaberg EC, Witt MD, Jacobson LP, Detels R, Rinaldo CR, Young S, Phair JP, Thio CL. Differences in hepatitis C virus prevalence and clearance by mode of acquisition among men who have sex with men. J Viral Hepat 2014 Oct; 21(10):696-705.
- Falade-Nwulia O, Seaberg EC, Snider AE, Rinaldo CR, Phair P, Witt WD, Thio CL. Incident hepatitis B in HIV-infected and HIV-uninfected men who have sex with men from pre-HAART to HAART periods: a cohort study. Ann Int Med; 2015 Nov; 163(9):673-80. PMCID PMC4630157
- 94. Vergara C, Thio C, Latanich R, Cox AL, Kirk GD, Mehta SH, Busch M, Murphy EL, Villacres MC, Peters MG, French AL, Golub E, Eron J, Lahiri CD, Shrestha S, Gustafson D, Young M, Anastos K, Aouizerat B, Kim AY, Lauer G, Thomas DL, Duggal P. Genetic basis for variation in plasma IL-18 levels in persons with chronic hepatitis C and human immunodeficiency virus-1 infections. Genes and Immunity, 2017 Mar; 18(2):82-87.
- 97. Price JC, Wang R, Seaberg EC, Budoff MJ, Kingsley LA, Palella FJ, Witt MD, Post WS, Thio CL. The association of inflammatory markes with nonalcoholic fatty liver disease differs by human immunodeficiency virus serostatus. OFID 2017 Jul; 4(3):ofx153