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Philip Jordan, PhD

  • Associate Professor

Departmental Affiliations

Contact Information

615 N. Wolfe Street
Room E8626
Baltimore, Maryland 21205

410-614-4773
+1 (410) 955 2926

Jordan Lab website

View Current Courses

Education

PhD, University of Edinburgh, 2006
BS, Flinders University of South Australia, 2001

Overview

Research in the Jordan laboratory focuses on understanding the molecular mechanisms regulating DNA repair, chromosome segregation and cell cycle progression. Their lab studies the importance of Structural Maintenance of Chromosomes (SMC) complexes and cell cycle kinases, particularly Polo-like (PLK) kinases and Aurora kinases. The Jordan lab uuse mouse as a model organism to study consequences of gene mutation and chromosome missegregation, which give rise to physical and mental developmental defects, infertility and cancer predisposition. They also use mouse and human pluripotent stem cells to help define the function of these proteins within essential molecular pathways of the cell.

Current research from the Jordan laboratory encompasses the following:

1) Gametogenesis (spermatogenesis and oogenesis)

2) Pluripotent stem cell preservation, proliferation, and differentiation

3) Neurodevelopment

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CURRENT LAB MEMBERS:

Philip Jordan - Principle Investigator

Marina Pryzhkova - Assistant Scientist

Michelle Xu - PhD student

Marnie Skinner - PhD student

Carter Simington - ScM Masters student

Kerstin Baran - ScM Masters student

GRADUATED STUDENTS:

Ayobami Ward - ScM Masters student - 2015

Himaja Gaddipati - ScM Masters student - 2015

Miebaka Jamabo - ScM Masters student - 2016

Zach Perdun - ScM Masters student - 2017

Maria Laura Reategui - ScM Masters student - 2018

Xueqi Zhao - ScM Masters student - 2018

Grace Hwang - PhD student - 2018

Jessica Hopkins - PhD student - 2018

Yujiao Zhang - ScM Masters student - 2019

Nathaniel Rogers - ScM Masters student - 2019

Stephen Wellard - PhD student - 2020

Tara Biser - PhD student - 2020

Alisa Boyko - PhD student - 2020

Chris Shults - ScM Masters student - 2020

Maggie Li - ScM Masters student - 2020

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Honors and Awards

2021: R01 NIH Research Grant, NIGMS

2019: R03 NIH Research Grant, NINDS

2018: Johns Hopkins University Catalyst Award

2017: KY Cha Award in Stem Cell Technology, ASRM

2017: Johns Hopkins Discovery Award

2017: R21 NIH Research Grant, ORIP

2016: R01 NIH Research Grant, NIGMS

2015: Johns Hopkins University Discovery Award

2014: Ho-Ching Yang Memorial Faculty Fellowship in Cancer Prevention

2013: R00 NIH Pathway to Independence Award, NICHD

2011: K99 NIH Pathway to Independence Award, NICHD

2010: US-UK Fulbright Distinguished Scholar Award, US-UK Fulbright Commission

2006: Federation of European Biochemical Societies Research Award

2005: Society for General Microbiology President’s Research Award and post-funding prize

2005: European Unions’ ERASMUS Student Mobility Award

2004: British Council - Austrian Academic Research Collaboration Award

2002: Darwin Trust International PhD Scholarship, University of Edinburgh, Scotland

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  • Genome maintenance
  • Meiosis
  • Embryonic stem cells
  • DNA recombination
  • Chromosome segregation
  • Structural Maintenance of Chromosomes (SMC)
  • SMC5/6
  • Cohesin, Condensin
  • Synaptonemal complex
  • Polo-like kinase (PLK)
  • Aurora kinase (AURK)

Selected example publications from the Jordan lab

  • Wellard SR, Zhang Y, Shults C, Zhao X, McKay M, Murray SA, Jordan PW (2021) Overlapping Roles for PLK1 and Aurora A kinases during Meiotic Centrosome Biogenesis in Mouse Spermatocytes. EMBO Rep. e51023.
  • Pryzhkova MP, Xu M and Jordan PW. (2020) Adaptation of the AID system for stem cell and transgenic mouse research. Stem Cell Research. (49): 102078.
  • Alisa Atkins, Michelle J. Xu, Maggie Li, Nathaniel P. Rogers, Marina V. Pryzhkova, Philip W. Jordan (2020) SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis. eLife. e61171.
  • Wellard S, Schindler K and Jordan PW (2020) Aurora B and Aurora C kinases regulate synaptonemal complex disassembly in male mice and humans. J. Cell Sci. 133: jcs248831.
  • Little T and Jordan PW. (2020) PLK1 is required for normal chromosome compaction and microtubule organization in mouse oocytes. Molecular Biology of the Cell. (31), 1206–1217.