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John Groopman, PhD

  • Edyth H. Schoenrich Professorship in Preventive Medicine
  • Professor

Departmental Affiliations

Center & Institute Affiliations

Contact Information

615 N. Wolfe Street
Room E7547
Baltimore, Maryland 21205

410-955-3900
410 955 0617

View Current Courses

Education

PhD, Massachusetts Institute of Technology, 1979
BA, Elmira College, 1974

Overview

The research in my program involves the development and application of molecular biomarkers of exposure, dose, and effect from environmental carcinogens. The environmental carcinogens studied include agents that are naturally occurring in the diet as well as those produced as a result of cooking practices. A major emphasis of the research has been in the elucidation of the role of aflatoxins, a common contaminate of the food supply, in the induction of liver cancer in high-risk populations living in Asia and Africa. This work has led to the identification of a very strong chemical-viral interaction between aflatoxin and the human hepatitis B virus in the induction of liver cancer. These biomarkers have also been used in many collaborative molecular epidemiology studies of liver cancer risk and recently employed to assess the efficacy of a number of chemopreventive agents in trials in high-risk aflatoxin-hepatitis B virus exposed populations. This research is now being extended to develop genetic biomarkers of p53 mutations and viral alterations in human samples as early detection of disease biomarkers using a novel mass spectroscopy based method for genotyping developed in the laboratory. Thus, the research in our laboratory focuses on the translation of mechanistic research to public health based prevention strategies.

Honors and Awards

2016 Ronald B. Herberman Memorial Speaker for National Cancer Prevention Day

2010 AACR-Prevent Cancer Foundation Award for Excellence in Cancer Prevention Research Award

2008 Gerald N. Wogan Lecture, Massachusetts Institute of Technology

National Cancer Institute Research Career Development Award

Delta Omega Honor Society in Public Health, Alpha Chapter

Phi Beta Kappa

  • Environmental Health Sciences, Chemical carcinogenesis
  • environmental carcinogenesis
  • chemoprevention
  • cancer prevention and control

Most recent and publications highlighting student research.

  • Chen, J-G, Johnson, JL, Egner, PA, Ng, DK, Zhu, J, Wang, J-B, Xue, X-F, Sun, Y, Zhang, Y-H, Lu, L-L, Chen, Y-S, Wu, Y, Zhu, Y-R, Carmella, SG, Hecht, SS, Jacobson, LP, Muñoz, A, Kensler, KH, Rule, A M, Fahey, JW, Kensler, TW, and Groopman, JD. Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China. American Journal of Clinical Nutrition, July 3 2019. 10.1093/ajcn/nqz12.
  • Groopman, JD. Environmental Health in the Biology Century: Transitions from Population to Personalized Prevention. Experimental Biology and Medicine, 244:728-733, 2019.
  • Brown, RH, Ng, DK, Steele, K. Schweitzer, M., and Groopman, JD. Mobilization of Environmental Toxicants Following Bariatric Surgery. Obesity, in press, 2019.
  • Koshiol, J., Gao, Y-T, Dean, M, Egner, PA, Nepal, C, Jones, K, Wang, B-S, Rashid, A, Luo, W, Van Dyke, A, Ferreccio, C, Malasky, M, Shen, M-C, Zhu, B, Andersen, JB, Hildesheim, A, Hsing, AW and Groopman, JD. Association Between Aflatoxin and Gallbladder Cancer in China. Gastroenterology, 153(2):488-494, 2017.
  • Livingstone, MC, Johnson, NM, Roebuck, BD, Kensler, TW and Groopman, JD. Profound changes in miRNA expression during cancer initiation by aflatoxin B1 and their abrogation by the chemopreventive triterpenoid CDDO-Im. Molecular Carcinogenesis, 56(11):2382-2390, 2017.