MD, Beijing Medical University, 1989
PhD, Peking University
I am an endocrinologist and have cared for both children and adults for more than 15 years. I have a broad training in clinical research, molecular epidemiology, and molecular biology laboratory. In the last decade, I have participated in a number of research studies on common chronic diseases such as obesity, type 2 diabetes, and metabolic syndrome and common pediatric problems such as preterm birth and metabolic consequences. My research bridged the gap between early life and adult diseases, and contributed new insight on early life origin of obesity and insulin resistance and diabetes.
I have been an active investigator of the Boston Birth Cohort (BBC, the parent population for this proposal) in the past 15 years. I have served as co-investigator and molecular genetics/ biomarker lab manager on multiple NIH-funded projects in the BBC. I have gained considerable experience in laboratory assay of molecular and genetic biomarkers, with a particular focus on incorporating molecular technology with epidemiological design to systematically investigate the environmental factors, nutritional biomarkers, genetic variants, and epigenetic alterations and their interactions in common metabolic diseases. I have authored and co-authored 60 publications in peer-reviewed scientific journals; some of them have appeared in prestigious journals such as JAMA, Nature communication, Diabetes, Diabetes Care, JAMA pediatrics, and the Journal of Clinical Endocrinology & Metabolism. My long term goal is to identify early life precursors of metabolic disorders such as obesity and metabolic syndrome and develop new prevention strategy.