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Xiaobin Wang, ScD

  • Zanvyl Krieger Professor in Children's Health
  • Director, Center on the Early Life Origins of Disease
  • Professor

Departmental Affiliations

Center & Institute Affiliations

Contact Information

615 N. Wolfe Street
Room E4132
Baltimore, Maryland 21205

410-955-5824
410.502.5831

http://www.jhsph.edu/departments/population-family-and-reproductive-health/center_on_early_life_origins_of_disease/index.html

View Current Courses

Education

ScD, Johns Hopkins Bloomberg School of Public Health, 1991
MPH, Tulane University School of Public Health and Tropical Medicine, 1987
MD, Beijing Medical University, 1983

Overview

Dr. Wang is a board certified pediatrician, maternal and child health researcher, and  molecular epidemiologist.  She directs the Center on Early Life Origins of Disease.  Her work unites biomarkers, clinical medicine, epidemiology, and disease prevention. She has served as the principal investigator (PI) of multiple large-scale molecular and genetic epidemiological studies funded by the National Institute of Health and Maternal and Child Health Bureau, with a particular focus on environmental factors, nutritional biomarkers, genetic variants, epigenetic and metabolomic alterations, and their interactions in complex human diseases, including reproductive and pregnancy outcomes, obesity, metabolic syndrome, food allergy and asthma, as well as autism and other developmental disabilities. 

Dr. Wang and her team have established three large study cohorts (Boston Birth Cohort, Chicago Family-based Cohort, and Chinese Twin Cohort).   Along with extensive epidemiological and clinical data as well as related biorepositories, these cohorts are well-designed for studying a broad range of health and disease outcomes and early life precursors of pediatric and adult diseases. 

Dr. Wang has authored and co-authored ~280 publications and many of them appear in prestigious medical journals, including the New England Journal of Medicine, Journal of the American Medical Association, and Lancet.  Her work has contributed to the understanding of environmental exposures, genetic susceptibility and gene-environment interactions in complex human diseases; and early life origins of chronic diseases.

Dr. Wang received her MD from Beijing Medical University in Beijing, China, and a master of public health from the School of Public Health and Tropical Medicine at Tulane University in New Orleans. She also received a doctor of science degree from the Department of Maternal and Child Health at the Johns Hopkins University School of Hygiene and Public Health in Baltimore. She completed a three-year research fellowship in Environmental Epidemiology at the Harvard University School of Public Health and a residency in pediatrics at the Boston University Medical Center.

Honors and Awards

1991 Inducted into Delta Omega, the Honorary Public Health Society

2001 Inducted into Society of Pediatric Research

2004 The Mary Ann & J. Milburn Smith Professorship, Children's Memorial Hospital and Children's Memorial Research Center, Northwestern University School of Medicine

2005 Elected Fellow of American Academy of Pediatrics (FAAP)

2012- Zanvyl Krieger professorship in Child Health and Development, Johns Hopkins University

2014 Inducted into American Pediatric Society

2015 Recipient of the Inaugural Mentor Award by the Student Association of PFRH, JHBSPH

2018 Johns Hopkins University Discovery Award

2018 Elected Member, the National Academy of Medicine

  • early life origins of disease
  • birth cohort study
  • gene-environment interactions
  • maternal and child health
  • pediatrics
  • preterm birth
  • obesity
  • hypertension
  • asthma
  • food allergies
  • autism
  • ADHD

Selected from over 280 peer-reviewed publications

  • Hong X, Hao K, Ji H, Peng S, Sherwood B, Narzo AD, Tsai HJ, Liu X, Burd I, Wang G, Ji Y, Caruso D, Mao G, Bartell TR, Zhang Z, Pearson C, Heffner L, Sandra Cerda, Terri H. Beaty, M Daniele Fallin, Lee-Parritz A, Zuckerman B, Weeks DE, Wang X. Genome-wide association study of preterm birth identified a significant gene-maternal pre-pregnancy BMI interaction in the Boston Birth Cohort. Nature Communication 2017 Jun 9;8:15608. doi: 10.1038/ncomms15608. PMID: 28598419
  • Zhang B, Hong X, Ji H, Tang WY, Kimmel M, Ji Y, Wang G, Pearson C, Zuckerman B, Surkan PJ, Wang X. Maternal smoking during pregnancy and cord blood DNA methylation: new insight on sex differences and effect modification by maternal folate. Epigenetics 2018 Jun 27. doi: 10.1080/15592294.2018.1475978. PMID: 29945474
  • Ji Y, Azuine RE, Zhang Yan, Hou W, Hong X, Wang G, Riley A, Pearson C, Zuckerman B, Wang X. Cord Plasma Biomarker of In-utero Acetaminophen Exposure and Risk of ADHD and ASD in Childhood. JAMA Psychiatry 2019 Oct 30:1-11. doi: 10.1001/jamapsychiatry.2019.3259. PMID: 31664451
  • Wang G, DiBari J, Bind E, Steffens AW, Mukherjee J, Bartell TR, Bellinger DC, Hong X, Ji Y, Wang MC, Wills-Karp M, Cheng TL, Wang X. In utero exposure to mercury and childhood overweight or obesity: counteracting effect of maternal folate status. BMC Med 17, 216 (2019) doi:10.1186/s12916-019-1442-2
  • Azuine, E.R. Ji, Y., Chang, H.Y., Kim, Y., Ji, H., DiBari, J., Hong, X., Wang, G., Singh, K.G. Pearson, C., Zuckerman, B., Surkan, J.P., Wang, X. Prenatal Risk Factors, Peri- and Post-natal Outcomes associated with Maternal Opioids Exposure in a U.S. Urban Low-Income Multi-Ethnic Population. JAMA Network Open. 2019 Jun 5;2(6):e196405. doi: 10.1001/jamanetworkopen.2019.6405. (see editorial comments)
  • A Prospective Birth Cohort Study on Pre- and Peri-natal Determinants of Autism Spectrum Disorders and Developmental Disabilities
  • Early Life Determinants of Obesity in U.S. Urban Low Income Minority Birth Cohort
  • MCHB Autism Longitudinal Data Project
  • Preterm Birth, Maternal and Cord Blood Metabolome, and Child Metabolic Risk