PhD, University of Pennsylvania, 1997
BS, Rutgers University, 1990
My research interests lie in understanding the interaction of viruses with the respiratory epithelium. Our efforts are primarily focused on influenza A virus, but we have interests in several other viruses including the severe, acute respiratory syndrome coronavirus (SARS-CoV), enterovirus-D68 (EV-D68), Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV) and Andes virus, a South American hantavirus responsible for Hanatavirus Pulmonary Syndrome (HPS).
There are two main focuses to our research program. The first is in how viral proteins target to sites of assembly and identifying the viral and cellular factors that are important for the production of infectious virus particles.
The second research focus of the laboratory is in understanding how viruses can counteract antiviral innate and adaptive immune responses. For these studies we utilize animal models of infection, as well as primary cell cultures of respiratory epithelial cells. By identifying the viral proteins that control the host immune response, we hope to gain a better understanding of how the virus can establish an infection and identify the key host proteins that play a role in controlling virus replication and the immune response to viral infection. In a related line of research, we are investigating how influenza A viruses can adapt to productively infect a new host. Of particular interest is the identification of viral and cellular factors that are important for efficient replication of canine, equine and avian influenza A virus strains to human respiratory epithelial cells.
Honors and Awards
2017 Delta Omega Honor Society in Public Health; 2016 Shikani/El Hibri Prize for Discovery and Innovation, Johns Hopkins Bloomberg School of Public Health; 2007 Diversity Leadership Award – Faculty, Washington University in St. Louis; 2001-03 Whitaker Foundation, Young Investigator Award; 2001-03 Infectious Diseases Society of America, Wyeth-Lederle Vaccines New Investigator Award; 2001 National Foundation for Infectious Diseases New Investigator Grant; 1995 Joel M. Dalrymple Memorial Award, American Society for Virology; 1989 Selman A. Waksman/David H. Struymeyer Award for Achievement in Biochemistry, Rutgers University