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Andrew Stanley Pekosz, PhD

  • Professor

Departmental Affiliations

Center & Institute Affiliations

Contact Information

615 N. Wolfe Street
Room W2116
Baltimore, Maryland 21205

410-502-9306

View Current Courses

Education

PhD, University of Pennsylvania, 1997
BS, Rutgers University, 1990

Overview

My research interests lie in understanding the interaction of viruses with the respiratory epithelium. Our efforts are primarily focused on influenza A virus and the severe, acute respiratory syndrome coronavirus-2 (SARS-CoV-2), but we have interests in several other viruses including, enterovirus-D68 (EV-D68), Influenza B virus and other emerging viruses.

There are two main focuses to our research program. The first is to understand how how virus proteins target to specific intracellular sites in order to mediate their function or to alter the function of host cell proteins and pathways.

The second research focus of the laboratory is in understanding how viruses interact with respiratory epithelial cells to mediate the early stages of infection. For these studies we utilize animal models of infection, as well as primary cell cultures of respiratory epithelial cells. By identifying the viral proteins that control infection of these specialized epithelial cells, we hope to gain a better understanding of how the virus can establish an infection and identify the key host proteins that play a role in controlling virus replication and the immune response to viral infection.

Honors and Awards

2020 Fellow of the American Academy of Microbiology; 2018 President of the American Society for Virology; 2017 Delta Omega Honor Society in Public Health; 2016 Shikani/El Hibri Prize for Discovery and Innovation, Johns Hopkins Bloomberg School of Public Health; 2007 Diversity Leadership Award – Faculty, Washington University in St. Louis; 2001-03 Whitaker Foundation, Young Investigator Award; 2001-03 Infectious Diseases Society of America, Wyeth-Lederle Vaccines New Investigator Award; 2001 National Foundation for Infectious Diseases New Investigator Grant; 1995 Joel M. Dalrymple Memorial Award, American Society for Virology; 1989 Selman A. Waksman/David H. Struymeyer Award for Achievement in Biochemistry, Rutgers University

  • virus
  • virus assembly
  • virus-host interactions
  • respiratory infections
  • receptors
  • cell tropism
  • vaccines
  • influenza
  • SARS-CoV-2
  • COVID-19
  • enterovirus-D68

Five publications that highlight the kind of research projects the Pekosz laboratory focuses on.

  • Powell H, Pekosz A. Neuraminidase antigenic drift of H3N2 clade 3c.2a viruses alters virus replication, enzymatic activity and inhibitory antibody binding. PLoS Pathog. 2020 Jun 29;16(6):e1008411. doi: 10.1371/journal.ppat.1008411. eCollection 2020 Jun. PMID: 32598381 Free PMC article.
  • Truong TT, Ryutov A, Pandey U, Yee R, Goldberg L, Bhojwani D, Aguayo-Hiraldo P, Pinsky BA, Pekosz A, Shen L, Boyd SD, Wirz OF, Röltgen K, Bootwalla M, Maglinte DT, Ostrow D, Ruble D, Han JH, Biegel JA, Li M, Huang C, Sahoo MK, Pannaraj PS, O'Gorman M, Judkins AR, Gai X, Dien Bard J. Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: A consecutive case series. EBioMedicine. 2021 May;67:103355. doi: 10.1016/j.ebiom.2021.103355. Epub 2021 Apr 26. PMID: 33915337
  • Dhakal S, Ruiz-Bedoya CA, Zhou R, Creisher P, Villano J, Littlefield K, Castillo J, Marinho P, Jedlicka A, Ordonez A, Majewska N, Betenbaugh M, Flavahan K, Mueller A, Looney M, Quijada D, Mota F, Beck SE, Brockhurst JK, Braxton A, Castell N, D'Alessio F, Metcalf Pate KA, Karakousis PC, Mankowski JL, Pekosz A, Jain SK, Klein SL. Sex differences in lung imaging and SARS-CoV-2 antibody responses in a COVID-19 golden Syrian hamster model. bioRxiv. 2021 Apr 4:2021.04.02.438292. doi: 10.1101/2021.04.02.438292. Preprint. PMID: 33821269
  • Wohlgemuth N1, Ye Y1, Fenstermacher KJ1, Liu H1, Lane AP, Pekosz2 A. The M2 protein of live, attenuated influenza vaccine encodes a mutation that reduces replication in human nasal epithelial cells. Vaccine. 2017 Dec 4;35(48 Pt B):6691-6699. doi: 10.1016/j.vaccine.2017.10.018. Epub 2017 Oct 25. PMID:29079099
  • Wohlgemuth N, Lane AP, Pekosz A. Influenza A Virus M2 Protein Apical Targeting Is Required for Efficient Virus Replication. J Virol. 2018 Oct 29;92(22):e01425-18. doi: 10.1128/JVI.01425-18. Print 2018 Nov 15. PMID: 30158290