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Andrew Stanley Pekosz, PhD

  • Professor

Departmental Affiliations

Center & Institute Affiliations

Contact Information

615 N. Wolfe Street
Room W2116
Baltimore, Maryland 21205

410-502-9306

View Current Courses

Education

PhD, University of Pennsylvania, 1997
BS, Rutgers University, 1990

Overview

My research interests lie in understanding the interaction of viruses with the respiratory epithelium. Our efforts are primarily focused on influenza A virus, but we have interests in several other viruses including the severe, acute respiratory syndrome coronavirus (SARS-CoV), enterovirus-D68 (EV-D68), Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV) and Andes virus, a South American hantavirus responsible for Hanatavirus Pulmonary Syndrome (HPS).

There are two main focuses to our research program. The first is in how viral proteins target to sites of assembly and identifying the viral and cellular factors that are important for the production of infectious virus particles.

The second research focus of the laboratory is in understanding how viruses can counteract antiviral innate and adaptive immune responses. For these studies we utilize animal models of infection, as well as primary cell cultures of respiratory epithelial cells. By identifying the viral proteins that control the host immune response, we hope to gain a better understanding of how the virus can establish an infection and identify the key host proteins that play a role in controlling virus replication and the immune response to viral infection. In a related line of research, we are investigating how influenza A viruses can adapt to productively infect a new host. Of particular interest is the identification of viral and cellular factors that are important for efficient replication of canine, equine and avian influenza A virus strains to human respiratory epithelial cells.

Honors and Awards

2017 Delta Omega Honor Society in Public Health; 2016 Shikani/El Hibri Prize for Discovery and Innovation, Johns Hopkins Bloomberg School of Public Health; 2007 Diversity Leadership Award – Faculty, Washington University in St. Louis; 2001-03 Whitaker Foundation, Young Investigator Award; 2001-03 Infectious Diseases Society of America, Wyeth-Lederle Vaccines New Investigator Award; 2001 National Foundation for Infectious Diseases New Investigator Grant; 1995 Joel M. Dalrymple Memorial Award, American Society for Virology; 1989 Selman A. Waksman/David H. Struymeyer Award for Achievement in Biochemistry, Rutgers University

  • virus
  • virus assembly
  • virus-host interactions
  • respiratory infections
  • receptors
  • cell tropism
  • vaccines
  • influenza
  • SARS-CoV
  • MERS-CoV
  • enterovirus-D68
  • hantavirus

Five most recent publications, highlighting work on virus assembly and virus-epithelial cell interactions.

  • Liu H1, Grantham ML1, Pekosz A2. Mutations in the Influenza A virus M1 protein enhance virus budding to complement lethal mutations in the M2 cytoplasmic tail. J Virol. 2017 Dec 14;92(1) pii: JVI.00858-17. doi: 10.1128/JVI.00858-17. PMID:29046451
  • Wohlgemuth N1, Ye Y1, Fenstermacher KJ1, Liu H1, Lane AP, Pekosz2 A. The M2 protein of live, attenuated influenza vaccine encodes a mutation that reduces replication in human nasal epithelial cells. Vaccine. 2017 Dec 4;35(48 Pt B):6691-6699. doi: 10.1016/j.vaccine.2017.10.018. Epub 2017 Oct 25. PMID:29079099
  • Forero A*, Fenstermacher K*,1, Wohlgemuth N1, Nishida A, Carter V, Smith EA, Peng X, Hayes M1, Francis D, Treanor J, Morrison J, Klein SL, Lane A, Katze MG, Pekosz A2. Evaluation of the innate immune responses to influenza and live-attenuated influenza vaccine infection in primary differentiated human nasal epithelial cells. Vaccine. 2017 Oct 27;35(45):6112-6121. doi: 10.1016/j.vaccine.2017.09.058. Epub 2017 Sep 28.PMID:28967519
  • Fischer WA II1, King LS, Lane AP and Pekosz A2. Restricted replication of the live attenuated influenza A virus vaccine during infection of primary, differentiated human nasal epithelial cells. Vaccine. 2015 Aug 26;33(36):4495-504. doi: 10.1016/j.vaccine.2015.07.023. Jul 18.PMID:26196325 PMCID:PMC4547880
  • Klein SL and Pekosz A. Sex-based biology and the rational design of vaccine strategies. J Infect Dis. 2014 Jul 15;209 Suppl 3:S114-9. doi: 10.1093/infdis/jiu066. PMID:24966191.