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Ann-Margret Ervin, PhD

  • Assistant Scientist

Departmental Affiliations

  • Epidemiology (Primary)
    • Division: General Epidemiology and Methodology
  • School of Medicine (Joint)

Center & Institute Affiliations

Contact Information

615 N. Wolfe Street
Room E6146
Baltimore, Maryland 21205


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PhD, Johns Hopkins University, 2006
MPH, Emory University, 1995


Dr. Ervin's research interests focus on the design and conduct of randomized clinical trials of interventions to treat and prevent ocular disease and visual impairment. Dr. Ervin has contributed to numerous studies of the causes, prevention, diagnosis or treatment of disorders of the eye and visual system including age-related macular degeneration, refractive error, low vision, cataract, and diabetic retinopathy.  She is currently the Co-Principal Investigator of the Data Coordinating Center for a multicenter observational study of Stargardt Disease and for a clinical trial of lutein and zeaxanthin for ocular and oculocutaneous albinism with colleagues at the Wilmer Eye Institute.  

Dr. Ervin also conducts novel research on the ethical implications of US federal regulations for institutional review boards (IRBs). Dr. Ervin is keenly interested in the impact of federal regulations on the design and conduct of multicenter clinical trials, specifically the advantages and disadvantages of alternate IRB review models for streamlining ethical review in the multicenter setting. She is currently the Co-Principal Investigator of an NIH-funded project to establish priorities for the principles and practices of central IRBs in the multicenter study setting. The project investigators will propose guidance for institutions and investigators involved in central IRB review of a multicenter clinical trial and for sponsors recommending use of central IRBs for multicenter trials.

Honors and Awards

Clinical Trials Training Program in Vision Research Fellowship, National Eye Institute, Johns Hopkins Bloomberg School of Public Health

Dean’s Scholar Academic Scholarship, Emory University

  • epidemiology
  • clinical trials
  • clinical trials methodology
  • visual impairment
  • eye disease
  • ophthalmology
  • optometry
  • bioethics
  • research ethics

Selected publications since 2012.

  • Ervin AM, Taylor HA, Ehrhardt S. NIH policy on single IRB review: a new era in ethical review of multicenter studies. New England Journal of Medicine, 2016 December 15; 375 (24): 2315 – 2317.
  • Ervin AM, Taylor HA, Meinert CL, Ehrhardt S. Evidence gaps and ethical review of multicenter studies. Science, 2015 November 6; 350 (6261): 632-3.
  • Al-Haddad C, Abdulaal M, Al-Moujahed A, Ervin AM. Fornix-based versus limbal-based conjunctival trabeculectomy flaps for glaucoma (Review). Cochrane Database of Systematic Reviews 2015 Issue 11 Art No.: CD009380. DOI: 10.1002/14651858.CD009380.pub2
  • Boland MV, Ervin AM, Friedman D, Jampel H, Hawkins B, Vollenweider D, Chelladurai Y, Ward D, Suarez-Cuervo C, Robinson KA Comparative Effectiveness of Treatments for Open-Angle Glaucoma: A Systematic Review. Annals of Internal Medicine 2013;158:271-279
  • Ervin AM, Boland MV, Myrowitz E, Prince J, Hawkins B, Vollenweider D, Ward D, Suarez-Cuervo C, Robinson KA. Comparative Effectiveness of Screening for Glaucoma. Comparative Effectiveness Review No. 59.  AHRQ Publication No. 12-EHC037-EF. Rockville, MD: Agency for Healthcare Research and Quality. 12 April 2012. PMID: 22649799
  • The Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar) Studies